Polymorphisms of toll-like receptors 2, 3 and 4 in patients that do and do not enter labour spontaneously at term

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dc.contributor.authorÖzlü, Tülay
dc.contributor.authorOcak, Zeynep
dc.contributor.authorSimavlı, Serap Aynur
dc.contributor.authorKarataş, Ahmet
dc.date.accessioned2021-06-23T19:35:42Z
dc.date.available2021-06-23T19:35:42Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractTo assess the association of polymorphisms of toll-like receptors (TLRs) 2, 3 and 4 with the delay in onset of labour at term pregnancies, patients delivering at >37 weeks and without pre-eclampsia, IUGR or a history of preterm delivery were prospectively evaluated. TLR2 Arg753Gln, TLR3 (c.1377C/T) and TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped by using PCR-RFLP. Patients labouring spontaneously before the 41st week were compared with those who did not labour spontaneously until this week in terms of baseline characteristics, TLR 2, 3 and 4 polymorphisms. The same comparisons were also performed by using a 40th week cut-off. Chi-square test, two-sample t-test or Mann-Whitney U tests were used for comparisons, as appropriate. In total, 79 patients delivering after 37 weeks were evaluated. All had CC genotype for TLR2 Arg753Gln and TLR4 Thr399Ile. There were no significant differences for TLR4 Asp299Gly GA and TLR3 (c.1377C/T) polymorphisms between patients spontaneously entering or not entering labour until the 41st week; the same was true when the 40th week cut-off was used. Delay in onset of labour at term pregnant women does not seem to be affected by the presence of TLR 2, 3 or 4 polymorphisms. Further studies are needed.en_US
dc.identifier.doi10.3109/01443615.2014.906392
dc.identifier.endpage478en_US
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue6en_US
dc.identifier.pmid24766260en_US
dc.identifier.scopus2-s2.0-84905049418en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage476en_US
dc.identifier.urihttps://doi.org/10.3109/01443615.2014.906392
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7847
dc.identifier.volume34en_US
dc.identifier.wosWOS:000340297200005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzlü, Tülay
dc.institutionauthorOcak, Zeynep
dc.institutionauthorKarataş, Ahmet
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Obstetrics And Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLabouren_US
dc.subjectTLR Polymorphismen_US
dc.subjectPost-term Pregnancyen_US
dc.titlePolymorphisms of toll-like receptors 2, 3 and 4 in patients that do and do not enter labour spontaneously at termen_US
dc.typeArticleen_US

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