Effects of melatonin on streptozotocin-induced diabetic liver injury in rats

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dc.authorid0000-0002-1501-9324
dc.authorid0000-0003-1937-9244
dc.authorid0000-0002-5800-3306
dc.authorid0000-0003-2339-5669
dc.authorid0000-0003-1691-618X
dc.authorid0000-0003-0572-8896
dc.authorid0000-0003-1083-7042
dc.contributor.authorGüven, Aysel
dc.contributor.authorYavuz, Özlem
dc.contributor.authorÇam, Meryem
dc.contributor.authorErcan, Feriha
dc.contributor.authorBukan, Neslihan
dc.contributor.authorÇomunoğlu, Cem
dc.contributor.authorGökçe, Fatih
dc.date.accessioned2021-06-23T19:19:28Z
dc.date.available2021-06-23T19:19:28Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThis study investigated the possible protective effects of melatonin as an antioxidant against streptozotocin (STZ)-induced diabetic liver injury in rats. Wistar rats were divided into four groups: untreated control (UC), melatonin-treated control (MC), untreated diabetic (UD), and melatonin-treated diabetic (MD). Experimental diabetes was induced by a single-dose (60 mg/kg, intraperitoneally (ip)) STZ injection, and metatonin was injected (200 wg/kg/day, ip) for 4 weeks. Upon light and electron microscopic examination, we observed that metatonin improved the morphological and histopathological changes of the liver caused by diabetes. Malondialdehyde levels in the liver homogenates of UD rats were higher than those of controls and were markedly reduced after melatonin treatment. Although no significant difference was observed with respect to antioxidant status, the superoxide dismutase activity tended to be higher in the UD rats than in the treated rats. Our findings showed that metatonin administration partially reduced liver injury in STZ-induced diabetic rats.en_US
dc.identifier.doi10.1016/j.acthis.2006.03.005
dc.identifier.endpage93en_US
dc.identifier.issn0065-1281
dc.identifier.issue2en_US
dc.identifier.pmid16714049en_US
dc.identifier.scopus2-s2.0-33745009246en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2006.03.005
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5946
dc.identifier.volume108en_US
dc.identifier.wosWOS:000239188000002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGüven, Aysel
dc.institutionauthorYavuz, Özlem
dc.institutionauthorÇam, Meryem
dc.institutionauthorGökçe, Fatih
dc.language.isoenen_US
dc.publisherElsevier Gmbh, Urban & Fischer Verlagen_US
dc.relation.ispartofActa Histochemicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectLiver Morphologyen_US
dc.subjectLipid Peroxidation Productsen_US
dc.subjectAnti-oxidative Statusen_US
dc.subjectMelatoninen_US
dc.titleEffects of melatonin on streptozotocin-induced diabetic liver injury in ratsen_US
dc.typeArticleen_US

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