Cytotoxic effects of nasal buserelin on nasal mucosal tissue in rabbits

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dc.contributor.authorOğhan, Fatih
dc.contributor.authorApuhan, Tayfun
dc.contributor.authorTerzi, Hakan
dc.contributor.authorKükner, Aysel
dc.contributor.authorÇoksuer, Hakan
dc.contributor.authorYılmaz, Fahrettin
dc.date.accessioned2021-06-23T19:29:31Z
dc.date.available2021-06-23T19:29:31Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractTo investigate the cytotoxic effects of nasal buserelin on rabbit nasal mucosal tissue, twenty-four female rabbits were studied prospectively. The rabbits were divided into 4 groups including 6 rabbits. The rabbits' left noses were included in the all study groups: 150 mu g/puff/day of buserelin acetate was administered topically twice daily during 21, 42 and 63 days. Saline was administered topically twice daily to the left nasal cavity in the control group. The nasal septal mucosal stripe tissue was carefully removed from underlaying cartilage after sedation. HE staining, Masson's trichrome, toluidine blue and TUNEL staining were used to evaluate mucosal changes. Each preparation was investigated via apoptotic cells, and they were accounted. Kruskal-Wallis test was used to evaluate nonparametric comparison of apoptotic cells. Mononuclear cells have been raised in the sub-epithelial connective tissue, nucleuses of epithelial cells in the apical region were pyknotic, and apoptotic cells were determined on 21-day group. In the 42-day group, nasal epithelial tissue was similar to 21-day group and epithelial cells including pyknotic nucleus were present in this group, too. In the 63-day group, epithelial cells were light colored. Venous sinuses in the sub-epithelial connective tissue were wide but not congested and not raised collagen filaments. In the intra-epithelial tissue, some of cells were TUNEL (+). Apoptotic cells were fewer in the control group according to 21-day group. In 42- and 63-day groups, these cells were fewer than in 21-day group. Numerical difference was present between the groups, but statistical significance was not found between the groups. We concluded that nasal buserelin cytotoxicity was not potent in the nasal cavity in rabbits. We use nasal buserelin in all indications with confidence.en_US
dc.identifier.doi10.1007/s00405-011-1866-6
dc.identifier.endpage1776en_US
dc.identifier.issn0937-4477
dc.identifier.issue7en_US
dc.identifier.pmid22160101en_US
dc.identifier.scopus2-s2.0-84864918979en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1771en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-011-1866-6
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7185
dc.identifier.volume269en_US
dc.identifier.wosWOS:000304700600007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorApuhan, Tayfun
dc.institutionauthorTerzi, Hakan
dc.institutionauthorKükner, Aysel
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives Of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBuserelin Acetateen_US
dc.subjectCytotoxicityen_US
dc.subjectNasal Mucosaen_US
dc.subjectRabbitsen_US
dc.titleCytotoxic effects of nasal buserelin on nasal mucosal tissue in rabbitsen_US
dc.typeArticleen_US

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