Cardioprotective effects of Viscum album L. subsp album (European misletoe) leaf extracts in myocardial ischemia and reperfusion

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dc.contributor.authorSuveren, Eylem
dc.contributor.authorBaxter, Gary F.
dc.contributor.authorİskit, Alper Bektaş
dc.contributor.authorTürker, Arzu Uçar
dc.date.accessioned2021-06-23T19:45:23Z
dc.date.available2021-06-23T19:45:23Z
dc.date.issued2017
dc.departmentBAİBÜ, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümüen_US
dc.description.abstractEthnopharmacological relevance: Viscum album L. (European mistletoe) is a hemiparasitic plant belonging to Loranthaceae family and has been used in Turkish traditional medicine for the treatment of cardiovascular disorders and heart diseases such as hypertension, tachycardia and angina pectoris. Aim of the study: The present study investigated the cardioprotective effects of V. album leaf extracts in myocardial ischemia and reperfusion injury in rats. Material and methods: Lyophilized aqueous (AVa) and methanolic (MVa) extracts of V. album were prepared from dried leaf. The isolated hearts were perfused with V. album extracts prior to and during 35 min of ischemia induced by coronary artery occlusion. After 120 min of coronary reperfusion, infarct size was determined by triphenyltetrazolium staining. Results: Both AVa and MVa extracts reduced the extent of infarction compared with untreated control hearts, but protective effect of MVa had more potential in low concentration; infarct size as proportion of ischemic risk zone: AVa 17.5 +/- 1.5%; Mva 20.3 +/- 2.5%, both P < 0.01 versus control 38.1 +/- 1.4%. This protective effect was comparable to infarct limitation induced by ischemic preconditioning (21.5 +/- 2.4%). Inhibition of nitric oxide synthesis with L-N-G-nitroarginine methyl ester completely abrogated the protection afforded by both extracts. ATP-sensitive K+ channel blockade by glibenclamide abrogated the protection afforded by MVa while attenuating, but not abolishing, the protective action of Ava. Conclusions: This study provided the first experimental evidence that V. album leaf extracts can mediate nitric oxide-dependent cardioprotection against myocardial injury produced by ischemia/reperfusion insult. With this study, popular usage of V. album extracts in Turkish folk medicine as a remedy for cardiac diseases was justified.en_US
dc.identifier.doi10.1016/j.jep.2017.07.010
dc.identifier.endpage209en_US
dc.identifier.issn0378-8741
dc.identifier.pmid28689799en_US
dc.identifier.scopus2-s2.0-85026529047en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage203en_US
dc.identifier.urihttps://doi.org/10.1016/j.jep.2017.07.010
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9145
dc.identifier.volume209en_US
dc.identifier.wosWOS:000411542700021en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSuveren, Eylem
dc.institutionauthorTürker, Arzu Uçar
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofJournal Of Ethnopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectViscum Albumen_US
dc.subjectCardioprotectionen_US
dc.subjectInfarct Sizeen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectNitric Oxideen_US
dc.subjectVasodilationen_US
dc.subjectLangendorffen_US
dc.subjectK-ATP Channelen_US
dc.titleCardioprotective effects of Viscum album L. subsp album (European misletoe) leaf extracts in myocardial ischemia and reperfusionen_US
dc.typeArticleen_US

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