Effects of intraperitoneal vitamin E, melatonin and aprotinin on leptin expression in the guinea pig eye during experimental uveitis

dc.authorid0000-0003-1364-4684
dc.authorid0000-0001-5387-2628
dc.authorid0000-0003-2039-9461
dc.contributor.authorKükner, Aysel
dc.contributor.authorÇolakoğlu, Nermin
dc.contributor.authorSerin, Didem
dc.contributor.authorAlagöz, Gürsoy
dc.contributor.authorÇelebi, Serdal
dc.contributor.authorKükner, A. Şahap
dc.date.accessioned2021-06-23T19:19:21Z
dc.date.available2021-06-23T19:19:21Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: To observe ultrastructural changes and leptin expression in the guinea pig eye during experimental uveitis (EU) and the effects of vitamin E, melatonin and aprotinin on leptin expression. Methods: Thirty male guinea pigs were randomly classified into five groups. Group 1 was the control group. Groups 2, 3, 4 and 5 received intravitreal injections of bovine serum albumin (BSA) to induce EU. At the same time on the third day, groups 3 (EU + vitamin E), 4 (EU + melatonin) and 5 (EU + aprotinin) received intraperitoneal vitamin E (150 mg/kg), melatonin (10 mg/kg) and aprotinin (20 000 IU/kg), respectively. On the sixth day, histopathological and clinical scoring of inflammation were performed, and leptin expression was investigated in the retina, choroid, sclera, episclera and cornea, and compared. Result: There was a remarkable increase in leptin expression in the retina, choroid, sclera and episclera in the EU group. Leptin expression in the treatment groups was similar to that in the control group. At light and electron microscopic levels, ganglion cells were oedematous and inner plexiform layer thickness had increased in the EU group retinas. Oedema was decreased in the treatment groups. Comparison of the EU and treatment groups revealed significant differences histopathologically and clinically. Conclusion: Experimental uveitis causes an increase in leptin expression in the retina, choroid, sclera and episclera of guinea pigs. Vitamin E, melatonin and aprotinin inhibit this increase. Leptin seems to be closely related to ocular inflammation.en_US
dc.identifier.doi10.1111/j.1600-0420.2005.00544.x
dc.identifier.endpage61en_US
dc.identifier.issn1395-3907
dc.identifier.issue1en_US
dc.identifier.pmid16445440en_US
dc.identifier.scopus2-s2.0-33644764090en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage54en_US
dc.identifier.urihttps://doi.org/10.1111/j.1600-0420.2005.00544.x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5925
dc.identifier.volume84en_US
dc.identifier.wosWOS:000234854300008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKükner, Aysel
dc.institutionauthorSerin, Didem
dc.institutionauthorAlagöz, Gürsoy
dc.institutionauthorÇelebi, Serdal
dc.institutionauthorKükner, A. Şahap
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofActa Ophthalmologica Scandinavicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExperimental Uveitisen_US
dc.subjectLeptinen_US
dc.subjectVitamin Een_US
dc.subjectAprotininen_US
dc.subjectMelatoninen_US
dc.titleEffects of intraperitoneal vitamin E, melatonin and aprotinin on leptin expression in the guinea pig eye during experimental uveitisen_US
dc.typeArticleen_US

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