Effect of breast milk calcium and fluidity on breast cancer cells: an in vitro cell culture study

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dc.authorid0000-0002-3060-1507
dc.authorid0000-0002-5650-1280
dc.authorid0000-0002-2604-5333
dc.contributor.authorBayram, Recep
dc.contributor.authorYavuz, Muhsine Zeynep
dc.contributor.authorBenek, Bedri Selim
dc.contributor.authorBozkurt, Ayşenur Aydoğar
dc.contributor.authorUcbek, Ali
dc.contributor.authorÖzünal, Zeynep Güneş
dc.contributor.authorGepdiremen, Akçahan
dc.date.accessioned2021-06-23T19:42:54Z
dc.date.available2021-06-23T19:42:54Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractAim: The aims of this study were to investigate the effects of calcium at the same concentration as that found in human milk on the viability, proliferation, and adhesion of MCF-7 human breast ductal carcinoma cells by exposing them to calcium at the same frequency as in breastfeeding. Materials and Methods: High-concentration calcium was applied for 30 minutes every 4 hours for 24, 48, and 72 hours. Cell proliferation and viability were measured using a hemocytometer and the MTT cell viability assay. The effects of calcium treatment were evaluated by a comparison among a multiple-, single-dose calcium treatment, and a control group. Results: We show that calcium at the same concentration as that in milk caused a decrease in the number of cells but did not affect cell viability. Conclusions: The results of this study suggest that calcium caused a lowering of the number of cells from the luminal surface of the breast by triggering proliferation under the condition of fluidity. Calcium and fluidity together serve to eliminate breast cancer stem cells during the lactation period. Effects of the other components of milk can be analyzed by the new method developed in this study.en_US
dc.identifier.doi10.1089/bfm.2016.0048
dc.identifier.endpage478en_US
dc.identifier.issn1556-8253
dc.identifier.issn1556-8342
dc.identifier.issue9en_US
dc.identifier.pmid27673412en_US
dc.identifier.scopus2-s2.0-84995486149en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage474en_US
dc.identifier.urihttps://doi.org/10.1089/bfm.2016.0048
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8636
dc.identifier.volume11en_US
dc.identifier.wosWOS:000387209700011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGepdiremen, Akçahan
dc.institutionauthorBayram, Recep
dc.institutionauthorYavuz, Muhsine Zeynep
dc.institutionauthorBenek, Bedri Selim
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofBreastfeeding Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCalciumen_US
dc.subjectFluidityen_US
dc.subjectCancer Preventionen_US
dc.subjectBreastfeedingen_US
dc.subjectMCF-7 Cellsen_US
dc.subjectCell Cultureen_US
dc.titleEffect of breast milk calcium and fluidity on breast cancer cells: an in vitro cell culture studyen_US
dc.typeArticleen_US

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