The detection of HBV DNA with polymerase chain reaction in blood donors with isolated hepatitis B core antibody

dc.authorid0000-0002-8637-6345
dc.contributor.authorTaş, Tekin
dc.contributor.authorKaya, Selçuk
dc.contributor.authorÖnal, Süleyman
dc.contributor.authorKüçükbayrak, Abdulkadir
dc.date.accessioned2021-06-23T19:29:21Z
dc.date.available2021-06-23T19:29:21Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAim To analyze the presence of HBV DNA in blood donors admitted to blood banks with HBsAg negativity and isolated anti-HBc positivity. Methods Sera samples of 2500 HBsAg negative donors were included in the study. HBsAg tests were assayed with VITROS analyzer. Anti-HBc total, anti-FIBs, HBeAg, anti-HBc and anti-HBc IgM tests were manually studied with DIA PRO kit by employing ELISA method. HBV DNA test was evaluated with iQ5 Real Time PCR Detection System with real-time PCR method. Results A total number of 401 (16.4%) HBsAg negative blood donors had anti-HBc positivity. Forty-five of 401 (1.8%) anti-HBc positive samples were anti-FIBs negative. These 45 persons were evaluated for anti-HBc positivity. Thirty-six of 45 anti-HBc positive persons had only anti-HBc positivity, and other nine patients had Anti-HBe antibody. HBV DNA was detected in three (6.6 %) of 45 isolated Anti-HBc positive persons as in one of nine persons and two of 36 persons. Conclusion The persons who have only FIBs Ag negativity may not be appropriate to become blood donors. Anti-HBc test should be done for HBsAg negative persons. They should not be accepted as blood donors if Anti-HBc is found positive.en_US
dc.identifier.endpage230en_US
dc.identifier.issn1840-0132
dc.identifier.issue2en_US
dc.identifier.pmid22926355en_US
dc.identifier.scopus2-s2.0-84868248311en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage227en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7158
dc.identifier.urihttps://search.ebscohost.com/login.aspx?direct=true&db=asn&AN=79820916&lang=tr&site=eds-live
dc.identifier.volume9en_US
dc.identifier.wosWOS:000307479600009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTaş, Tekin
dc.institutionauthorKüçükbayrak, Abdülkadir
dc.language.isoenen_US
dc.publisherMedical Assoc Zenicadoboj Cantonen_US
dc.relation.ispartofMedicinski Glasniken_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-HBc Aloneen_US
dc.subjectBlood Banksen_US
dc.subjectDNAen_US
dc.titleThe detection of HBV DNA with polymerase chain reaction in blood donors with isolated hepatitis B core antibodyen_US
dc.typeArticleen_US

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