The role of interim PET/CT on survival in diffuse large B cell lymphoma

Basit Öğe Kaydı
dc.authorid0000-0002-4303-9488en_US
dc.authorid0000-0002-5603-1178en_US
dc.authorid0000-0002-1430-0341en_US
dc.authorid0000-0002-2596-4493en_US
dc.authorid0000-0001-9556-8915en_US
dc.contributor.authorMengüç, Meral Uluköylü
dc.contributor.authorMehtap, Özgür
dc.contributor.authorGörür, Gözde Dağlıöz
dc.contributor.authorAteşoglu, Elif Birtaş
dc.contributor.authorGedük, Ayfer
dc.contributor.authorÜnal, Serkan
dc.date.accessioned2023-07-21T10:31:36Z
dc.date.available2023-07-21T10:31:36Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractDiffuse large B cell lymphoma is an aggressive lymphoma which fails to cure in first line almost in one third of patients. Earlier risk assessment and tailoring therapy with interim PET will select a group of patients having high risk to relapse. Although interim PET guided therapy has been established in Hodgkin Lymphoma; the role of interim PET in non-Hodgkin lymphomas is debated. In this study we searched the association of interim PET on survival in 103 DLBCL patients.Interim PET assessed by 5-point Deauville Score predicts PFS and OS with a PPV of 65.4% and a NPV of 77.9%. Background: Diffuse large B cell lymphoma is the most frequent aggressive non-Hodgkin lymphoma. Predicting response and estimating prognosis earlier makes management of this heterogeneous lymphoma more satisfying. Interim PET response is established in Hodgkin Lymphoma to tailor the therapy but results for non-Hodgkin Lymphoma is unconvincing. In the current study evaluation of interim PET and survival outcomes of 103 DLBCL patients is performed. Patients and Methods: About 103 Patients with DLBCL followed up in a single center between 2009 and 2019 were enrolled the study. All patients received R-CHOP chemoimmunotherapy at first line. Interim PET was performed after at least one or more cycles. All PET scans were performed with 18 F-FDG isotope as PET/CT. PET scoring results were evaluated according to the 5-Point Deauville Scoring system defined in the National Comprehensive Cancer Network clinical guidelines for iPET and eotPET. 5-P DS of scores of 1 to 3 were defined as negative scans, and scores of 4 to 5 were considered to be positive scans. Results: Forty-six (44.7%) Female and 57 (55.3%) male aged between 25 and 83 (median 57) years newly diagnosed DLBCL patients were enrolled in the study. Median PFS was 21 (interquartile range 8.5-53.7) months and median OS was 33.5 (interquartile range 12.5-62.9) months for the total cohort. Positive predictive value of interim PET according to Deauville scoring system was 65.4% and negative predictive value was 77.9%. Conclusion: Our study showed that according to Deauville 5 point scale (D 5PS) scoring system, interim PET-positive patients have shorter both PFS and OS than iPET-negative patients. (C) 2021 Elsevier Inc. All rights reserved.en_US
dc.identifier.citationMengüç, M. U., Mehtap, Ö., Görür, G. D., Ateşoğlu, E. B., Gedük, A., Ünal, S., ... & Hacıhanefioğlu, A. (2021). The role of interim PET/CT on survival in diffuse large B cell lymphoma. Clinical Lymphoma Myeloma and Leukemia, 21(11), e922-e927.en_US
dc.identifier.doi10.1016/j.clml.2021.06.016
dc.identifier.endpageE927en_US
dc.identifier.issn2152-2650
dc.identifier.issn2152-2669
dc.identifier.issue11en_US
dc.identifier.pmid34353778en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE922en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.clml.2021.06.016
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11327
dc.identifier.volume21en_US
dc.identifier.wosWOS:000713462500014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMengüç, Meral Uluköylü
dc.language.isoenen_US
dc.publisherCIG Media Group LPen_US
dc.relation.ispartofClinical Lymphoma Myeloma & Leukemiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDLBCLen_US
dc.subjectPrognosisen_US
dc.subjectSurvivalen_US
dc.subjectPositron-Emission-Tomographyen_US
dc.subjectClinical-Practice Guidelinesen_US
dc.subjectFDG-PETen_US
dc.titleThe role of interim PET/CT on survival in diffuse large B cell lymphomaen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
meral-ulukoylu-menguc.pdf
Boyut:
569.08 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu