The role of interim PET/CT on survival in diffuse large B cell lymphoma
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Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
CIG Media Group LP
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Diffuse large B cell lymphoma is an aggressive lymphoma which fails to cure in first line almost in one third of patients. Earlier risk assessment and tailoring therapy with interim PET will select a group of patients having high risk to relapse. Although interim PET guided therapy has been established in Hodgkin Lymphoma; the role of interim PET in non-Hodgkin lymphomas is debated. In this study we searched the association of interim PET on survival in 103 DLBCL patients.Interim PET assessed by 5-point Deauville Score predicts PFS and OS with a PPV of 65.4% and a NPV of 77.9%. Background: Diffuse large B cell lymphoma is the most frequent aggressive non-Hodgkin lymphoma. Predicting response and estimating prognosis earlier makes management of this heterogeneous lymphoma more satisfying. Interim PET response is established in Hodgkin Lymphoma to tailor the therapy but results for non-Hodgkin Lymphoma is unconvincing. In the current study evaluation of interim PET and survival outcomes of 103 DLBCL patients is performed. Patients and Methods: About 103 Patients with DLBCL followed up in a single center between 2009 and 2019 were enrolled the study. All patients received R-CHOP chemoimmunotherapy at first line. Interim PET was performed after at least one or more cycles. All PET scans were performed with 18 F-FDG isotope as PET/CT. PET scoring results were evaluated according to the 5-Point Deauville Scoring system defined in the National Comprehensive Cancer Network clinical guidelines for iPET and eotPET. 5-P DS of scores of 1 to 3 were defined as negative scans, and scores of 4 to 5 were considered to be positive scans. Results: Forty-six (44.7%) Female and 57 (55.3%) male aged between 25 and 83 (median 57) years newly diagnosed DLBCL patients were enrolled in the study. Median PFS was 21 (interquartile range 8.5-53.7) months and median OS was 33.5 (interquartile range 12.5-62.9) months for the total cohort. Positive predictive value of interim PET according to Deauville scoring system was 65.4% and negative predictive value was 77.9%. Conclusion: Our study showed that according to Deauville 5 point scale (D 5PS) scoring system, interim PET-positive patients have shorter both PFS and OS than iPET-negative patients. (C) 2021 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
DLBCL, Prognosis, Survival, Positron-Emission-Tomography, Clinical-Practice Guidelines, FDG-PET
Kaynak
Clinical Lymphoma Myeloma & Leukemia
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
21
Sayı
11
Künye
Mengüç, M. U., Mehtap, Ö., Görür, G. D., Ateşoğlu, E. B., Gedük, A., Ünal, S., ... & Hacıhanefioğlu, A. (2021). The role of interim PET/CT on survival in diffuse large B cell lymphoma. Clinical Lymphoma Myeloma and Leukemia, 21(11), e922-e927.