Effects of isotretinoin on new bone formation after maxillary sutural expansion

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dc.authorid0000-0003-3624-566X
dc.authorid0000-0001-5400-0012
dc.authorid0000-0003-2261-6925
dc.contributor.authorBulut, Musa
dc.contributor.authorKorkmaz, Yasemin Nur
dc.contributor.authorErimşah, Sevilay
dc.date.accessioned2021-06-23T19:53:51Z
dc.date.available2021-06-23T19:53:51Z
dc.date.issued2020
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Ortodonti Ana Bilim Dalıen_US
dc.description.abstractPurpose The aim of this study was to examine the effects of isotretinoin on new bone formation after maxillary sutural expansion in rats. Materials and methods A total of 32 maleWistar rats were selected and randomly divided into four groups. The isotretinoin group was treated with 7.5mg/kg isotretinoin, and the soybean group was treated with 2ml/kg soybean oil for 57 days. The substances were applied via oral gavage. The expansion-only and the control groups were not treated with any substance. In the experiment groups, expansion springs were applied on day 41 of the experiment, and after day 5 of expansion, a 12-day retention period was established. At the end of the experiment, all the animals were sacrificed, and their maxillae were dissected for histological evaluation. The numbers of osteoclasts, osteoblasts and formation of new bone and capillaries were evaluated on slides centered around the suture. Results The statistical analysis showed significant differences between the groups for the number of osteoblasts and osteoclasts (p< 0.001). In the experiment groups, higher numbers of osteoblasts and osteoclasts were detected in comparison to the control group (p< 0.001), while there was no significant difference between the experiment groups. Capillary formation and new bone formation in the isotretinoin group were found to be on a higher level than in the other groups (p< 0.001). Conclusion Isotretinoin had no negative effects on bone formation following the expansion of the maxillary suture in rats.en_US
dc.identifier.doi10.1007/s00056-019-00209-2
dc.identifier.endpage446en_US
dc.identifier.issn1434-5293
dc.identifier.issn1615-6714
dc.identifier.issue6en_US
dc.identifier.pmid31965210en_US
dc.identifier.scopus2-s2.0-85078261505en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage440en_US
dc.identifier.urihttps://doi.org/10.1007/s00056-019-00209-2
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10298
dc.identifier.volume81en_US
dc.identifier.wosWOS:000580519300006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBulut, Musa
dc.institutionauthorErimşah, Sevilay
dc.institutionauthorKorkmaz, Yasemin Nur
dc.language.isoenen_US
dc.publisherUrban & Vogelen_US
dc.relation.ispartofJournal Of Orofacial Orthopedics-Fortschritte Der Kieferorthopadieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnimal experimentationen_US
dc.subjectRatsen_US
dc.subjectOsteogenesisen_US
dc.subjectBone dDevelopmenten_US
dc.subjectPalatal Expansion Techniqueen_US
dc.titleEffects of isotretinoin on new bone formation after maxillary sutural expansionen_US
dc.typeArticleen_US

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