Comparison of anti HCV signal-to-cutoff ratio with HCV RNA results

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dc.authorid0000-0002-6011-7775en_US
dc.authorid0000-0002-5676-6983en_US
dc.authorid0000-0003-2183-7080en_US
dc.contributor.authorAvcıoğlu, Fatma
dc.contributor.authorBehçet, Mustafa
dc.contributor.authorKalaycıoğlu, Oya
dc.date.accessioned2023-05-17T11:59:58Z
dc.date.available2023-05-17T11:59:58Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Anti-HCV antibody level screening is used in the diagnosis of HCV. However, a positive (S/Co > 1) result in the anti-HCV test does not always reflect true positivity. Antibody level results of S/Co ratio > 1 have to be validated through HCV RNA. In this study, we aimed to compare the signal-to-cutoff ratios of patients with positive (> 1) HCV antibody levels with the results of HCV RNA by PCR. Methods: In total, 17,021 samples were tested for anti HCV between January 2017 and December 2019. HCV antibody (anti HCV) was performed with a fully automated chemiluminescent microparticle immunoassay (CMIA, Abbot (R), Architect System). Real Time PCR test (Anatolia Geneworks HCV, Turkey) was used as nucleic acid amplification method. Results: Of the 17,021 patients, 16,706 (98.15%) tested negative and 315 (1.85%) tested positive in the anti-HCV assay. An additional HCV RNA test was requested for these 315 patients with positive anti-HCV assay results (S/Co >= 1) of which 23.81% (75/315) were positive for HCV RNA in serum, with a median (IQR): 5.43 log(10) IU/mL (4.75 - 6.01 log(10) IU/mL). Patients who tested positive for HCV RNA had significantly higher S/Co values compared to patients who tested negative (median (IQR): 13.38 (12.30 - 14.57) vs. 1.79 (1.34 - 1.79), p < 0.001). Conclusions: When S/Co ratios of patients who tested anti-HCV positive and HCV RNA positive were evaluated, it was assumed that high S/Co values were more relevant to true positivity. It was also concluded that low S/Co ratios needed to be verified through PCR.en_US
dc.identifier.citationAvcioglu, F., Behcet, M., & Kalaycioglu, O. (2021). Comparison of Anti HCV Signal-to-Cutoff Ratio with HCV RNA Results. Clinical laboratory, 67(2), 376-380.en_US
dc.identifier.doi10.7754/Clin.Lab.2020.200738
dc.identifier.endpage380en_US
dc.identifier.issn1433-6510
dc.identifier.issue2en_US
dc.identifier.pmid33616333en_US
dc.identifier.scopus2-s2.0-85102222176en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage376en_US
dc.identifier.urihttp://dx.doi.org/10.7754/Clin.Lab.2020.200738
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10905
dc.identifier.volume67en_US
dc.identifier.wosWOS:000648744300023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAvcıoğlu, Fatma
dc.institutionauthorBehçet, Mustafa
dc.institutionauthorKalaycıoğlu, Oya
dc.language.isoenen_US
dc.publisherClinical Laboratory Publicationen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti HCVen_US
dc.subjectHCV RNAen_US
dc.subjectScreening Testen_US
dc.subjectHepatitis-Cen_US
dc.subjectVirusen_US
dc.titleComparison of anti HCV signal-to-cutoff ratio with HCV RNA resultsen_US
dc.typeArticleen_US

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