Determination of anti-nuclear antibody pattern distribution and clinical relationship

Basit Öğe Kaydı
dc.authorid0000-0001-7306-5233en_US
dc.authorid0000-0003-0727-1797en_US
dc.authorid0000-0002-9026-4485en_US
dc.authorid0000-0002-5643-3038
dc.contributor.authorMengeloğlu, Zafer
dc.contributor.authorTaş, Tekin
dc.contributor.authorKoçoğlu, Esra
dc.contributor.authorAktaş, Gülali
dc.contributor.authorKarabörk, Şeyda
dc.date.accessioned2021-06-23T19:36:14Z
dc.date.available2021-06-23T19:36:14Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground and Objectives: Autoantibodies are innmunglobulins occurred directly against autoantigens that are known as endogen antigens. Autoinnmune disease is an occasion that the body begins a fight against its own cells and tissues. The antibodies that are created by the body against its own cell nuclei are called as anti-nuclear antibodies (ANA), and one of the methods used for detection and pattern of ANA is indirect immunofluorescence test (IIF). In the present study, it was aimed to determine the rate of ANA positivity and patterns of the positive specimens, and to investigate the relationship between ANA positivity and diseases in patients. Methods: ANA test results of a total of 3127 patients admitted during March 2010 to December 2012 were evaluated retrospectively. ANA test (HEp 20-10, EUROIMMUN, Germany) was used in dilution of 1:100 in IIF test. Results: A total of 494 (15.8%) resulted as ANA positive. ANA positivity rate was significantly higher in female patients than the male ones (p < 0.001). The most frequent ANA patterns were coarse speckled pattern (154 patients, 31.2%), nucleolar pattern (89 patients, 18.0%), fine speckled pattern (57 patients, 11.5%), and speckled pattern (48 patients, 9.7%). ANA positivity was most commonly determined in rheumatoid arthritis (RA) (42 patients, 8.5%), systemic lupus erythematosus (SLE) (29 patients, 5.9%), and rheumatoid vasculitis (RV) (28 patients, 5.7%). The most frequent symptoms or findings were joint pain (127 patients, 26.0%) and anemia (28 patients, 5.7%). ANA positivity rates were found to be significantly higher in patients with RA (p < 0.001), with SLE (p < 0.001), and with Raynaud phenomenon (p=0.001) in comparison to the controls. Amongst the most frequent diseases evaluated, no significant differences were found between the control groups and the groups of RV (p=0.089), multiple sclerosis (p=0.374), and Sjogren syndrome (p=0.311) in terms of ANA positivity rates. Conclusions: The present study is the first study reporting the positivity rate and distribution of ANA in Bolu located in northwestern Turkey. Information about the pattern types and the distribution of the patterns according to the diseases and symptoms contribute in diagnosis of autoimmune diseases. It is observed that clinical diagnosis has been supported significantly by ANA test according to data of our study.en_US
dc.identifier.endpage383en_US
dc.identifier.issn1682-024X
dc.identifier.issue2en_US
dc.identifier.pmid24772147en_US
dc.identifier.scopus2-s2.0-84896839909en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage380en_US
dc.identifier.urihttp://pjms.com.pk/index.php/pjms/article/view/4276/2254
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7955
dc.identifier.volume30en_US
dc.identifier.wosWOS:000334562700031en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMengeloğlu, Zafer
dc.institutionauthorTaş, Tekin
dc.institutionauthorKoçoğlu, Esra
dc.institutionauthorAktaş, Gülali
dc.institutionauthorKarabörk, Şeyda
dc.language.isoenen_US
dc.publisherProfessional Medical Publicationsen_US
dc.relation.ispartofPakistan Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnti-nuclear Antibodyen_US
dc.subjectANAen_US
dc.subjectIIFen_US
dc.subjectImmunfluorescenceen_US
dc.titleDetermination of anti-nuclear antibody pattern distribution and clinical relationshipen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
zafer-mengeloglu-7955.pdf
Boyut:
935.67 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin/Full text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Temel Tıp Bilimleri Bölümü Koleksiyonu