Serum oxidant and antioxidant levels in diesel exposed toll collectors

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dc.authorid0000-0002-7661-8830en_US
dc.authorid0000-0001-5730-0790
dc.authorid0000-0003-1937-9244
dc.authorid0000-0003-1691-618X
dc.authorid0000-0002-7413-1367
dc.contributor.authorArbak, Peri
dc.contributor.authorYavuz, Özlem
dc.contributor.authorBukan, Neslihan
dc.contributor.authorBalbay, Öner
dc.contributor.authorÜlger, Füsün
dc.contributor.authorAnnakkaya, Ali Nihat
dc.date.accessioned2021-06-23T19:17:56Z
dc.date.available2021-06-23T19:17:56Z
dc.date.issued2004
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractSerum Oxidant and Antioxidant Levels in Diesel Exposed Toll Collectors: Peri ARBAK, et al. Department of Chest Diseases, Abant Izzet Baysal University, Duzce School of Medicine, Turkey-it has been suggested that exposure to diesel exhaust may lead to adverse effects due to the generation of oxidants. To evaluate the end products of oxidative stress in DE exposure, toll collectors who are considered a high risk group in regard to occupational toxins were compared to controls who had office-based occupations in the same company in this cross sectional study. A total of 38 toll collectors constituted the study group. All subjects were male. The toll collectors and 29 controls were similar regarding age, smoking status and duration of work. All subjects underwent a clinical examination and an interviewer-administrated questionnaire regarding respiratory symptoms, past medical and occupational history, and pulmonary function tests were performed in all subjects. Serum malondialdehyde (MDA), nitrite+nitrate and vitamin E levels were measured. Toll collectors showed higher serum MDA (5.76 +/- 2.15 mumol/L vs. 3.07 +/- 0.76 mumol/L, p=0.0001) and nitrite+nitrate levels (96.50 +/- 45.54 mumol/L vs. 19.32 +/- 11.77 mumol/L, p=0.0001) than controls. Vitamin E levels were similar in toll collectors and controls (10.57 +/- 3.44 mg/L and 9.72 +/- 2.44 mg/L, respectively, p=0.267). There was no difference between groups in terms of the findings of clinical examinations and respiratory symptoms. In pulmonary function parameters, only peak expiratory flow (PEF) in toll collectors was significantly lower than that of controls (88.9% predicted and 104.2% predicted, respectively, p=0.012). In conclusion, we suggest that serum MDA and nitrite+nitrate levels may be used as biological markers of oxidative stress related to DE exposure, but prospective controlled clinical studies are necessary to clarify the possible association between concentrations of MDA and nitrite+nitrate and pulmonary diseases related to DE exposure.en_US
dc.identifier.doi10.1539/joh.46.281
dc.identifier.endpage288en_US
dc.identifier.issn1341-9145
dc.identifier.issn1348-9585
dc.identifier.issue4en_US
dc.identifier.pmid15308827en_US
dc.identifier.scopus2-s2.0-4143118793en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage281en_US
dc.identifier.urihttps://doi.org/10.1539/joh.46.281
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5591
dc.identifier.volume46en_US
dc.identifier.wosWOS:000223257800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorArbak, Peri
dc.institutionauthorYavuz, Özlem
dc.institutionauthorBalbay, Öner
dc.institutionauthorAnnakkaya, Ali Nihat
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Occupational Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOccupationen_US
dc.subjectMDA
dc.subjectNitrite+Nitrate
dc.subjectVitamin E
dc.subjectToll Collectors
dc.subjectDiesel Exhaust
dc.titleSerum oxidant and antioxidant levels in diesel exposed toll collectorsen_US
dc.typeArticleen_US

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