Investigating the effects of carvacrol in rats using oxygen-induced retinopathy model

Basit Öğe Kaydı
dc.authorid0000-0003-1018-925Xen_US
dc.authorid0000-0003-4468-3985en_US
dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0001-5400-0012en_US
dc.contributor.authorKaymaz, Abdulgani
dc.contributor.authorUlaş, Fatih
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorErimşah, Sevilay
dc.date.accessioned2023-05-30T13:47:06Z
dc.date.available2023-05-30T13:47:06Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: Investigating the effects of intraperitoneal carvacrol administration in rats using the oxygen-induced retinopathy (OIR) model. Methods: A total of 28 newborn Sprague Dawley rats were used and the OIR model was created using the 50/10% oxygen model. The study composed of four groups in total. While the OIR model was not used in Group I (control group), it was created for Groups II, III, and IV. About 0.01 mL carvacrol, bevacizumab, or 0.9% NaCl was administered intraperitoneal (IP) to the rats in all groups on postnatal day (PND) 14 as follows: Group I and Group II were administered 0.9% NaCl, Group III was administered bevacizumab, and Group IV was administered carvacrol. On PND 18, rats were sacrificed and their right eyes were enucleated. Results: Histopathological and immunohistochemical studies showed that the number of vascular endothelial cells (VECs), vascular endothelial growth factor (VEGF), and tumor necrosis factor-alpha (TNF-alpha) decreased similarly in Group III and Group IV compared with Group II. VECs values for Group I, Group II, Group III, and Group IV were measured as 0 +/- 0, 26.45 +/- 4.57, 7.75 +/- 1.98, and 5.78 +/- 1.72, respectively, and it differed significantly between groups (P < 0.001). Likewise, VEGF levels were observed as 0.06 +/- 0.01, 3.31 +/- 0.53, 2.47 +/- 0.44, and 2.49 +/- 0.52, respectively, and it differed significantly between groups (P < 0.001). TNF-alpha levels were recorded as 0.06 +/- 0.01, 3.58 +/- 0.38, 2.46 +/- 0.49, and 2.29 +/- 0.25, respectively, and it differed significantly between groups (P < 0.001). VECs, VEGF, and TNF-alpha were similar between Group III and IV (range of P values were 0.486-0.998). Conclusion: The study demonstrated that carvacrol significantly reduced retinal pathological angiogenesis, NV, VEC nuclei count, VEGF, and TNF-alpha levels. Moreover, the observed effects were comparable to those of bevacizumab.en_US
dc.identifier.citationKaymaz, A., Ulaş, F., Çetinkaya, A., & Erimşah, S. (2021). Investigating the effects of carvacrol in rats using oxygen-induced retinopathy model. Indian Journal of Ophthalmology, 69(5), 1219.en_US
dc.identifier.doi10.4103/ijo.IJO_1935_20
dc.identifier.endpage1223en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.issue5en_US
dc.identifier.pmid33913864en_US
dc.identifier.scopus2-s2.0-85105053476en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1219en_US
dc.identifier.urihttp://dx.doi.org/10.4103/ijo.IJO_1935_20
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11010
dc.identifier.volume69en_US
dc.identifier.wosWOS:000647111200043en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaymaz, Abdulgani
dc.institutionauthorUlaş, Fatih
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorErimşah, Sevilay
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBevacizumaben_US
dc.subjectCarvacrolen_US
dc.subjectNeovascularizationen_US
dc.subjectOxygen-Induced Retinopathyen_US
dc.subjectRetinopathy of Prematurityen_US
dc.titleInvestigating the effects of carvacrol in rats using oxygen-induced retinopathy modelen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
abdulgani-kaymaz.pdf
Boyut:
4.01 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Temel Tıp Bilimleri Bölümü Koleksiyonu