A comparison of IL-17 and IL-34 concentrations in the cerebrospinal fluid of patients with acute inflammatory demyelinating neuropathy and chronic inflammatory demyelinating polyneuropathy

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dc.authorid0000-0002-0000-3768en_US
dc.authorid0000-0002-5308-4653
dc.contributor.authorSoytürk, Hayriye
dc.contributor.authorYılmaz, Murat
dc.date.accessioned2021-06-23T19:53:51Z
dc.date.available2021-06-23T19:53:51Z
dc.date.issued2020
dc.departmentBAİBÜ, Ziraat Fakültesi, Kanatlı Hayvan Yetiştiriciliği Bölümüen_US
dc.description.abstractOBJECTIVE: The role of interleukins, such as IL-17 and IL-34, in the pathogenesis of autoimmune diseases has been established in the literature. In the current study, we aimed to identify the concentrations of IL-17 (IL-17A, IL-17F) and IL-34 in the cerebrospinal fluid (CSF) of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and acute inflammatory demyelinating neuropathy (AIDN). METHODS: We included in this study 8 patients with CIDP (none of them receiving immunomodulatory or immunosuppressant therapy), 7 patients with Guillain-Barre syndrome (GBS, AIDN), and 7 control subjects. The CIDP and AIDN diagnoses were made by clinical evaluation and electrophysiological investigations according to international criteria. CSF samples were obtained appropriately, and the levels of IL-17A, IL-17F, and IL-34 were measured by ELISA kits. RESULTS: The concentrations of IL-17A, IL-17F, and IL-34 were higher in those with CIDP and AIDN compared to the controls (p=0.005, p=0.01, and p=0.001, respectively). While IL-34 levels were significantly higher in AIDN patients than in CIDP patients (p=0.04), there were no significant differences between the AIDN and CIDP groups with regard to the levels of IL-17A and IL-17F (p=0.4 and p=0.2, respectively) CONCLUSION: Our results indicate that IL-17A, IL-17F, and IL-34 levels may have a role in CIDP and AIDN. Furthermore, the difference in the IL-34 levels of patients with AIDN and CIDP may indicate an important difference between the pathogenesis of these two sets of the disease.en_US
dc.identifier.doi10.1590/1806-9282.66.11.1583
dc.identifier.endpage1588en_US
dc.identifier.issn1806-9282
dc.identifier.issue11en_US
dc.identifier.pmid33295414en_US
dc.identifier.scopus2-s2.0-85097516604en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1583en_US
dc.identifier.urihttps://doi.org/10.1590/1806-9282.66.11.1583
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10291
dc.identifier.volume66en_US
dc.identifier.wosWOS:000595815500026en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSoytürk, Hayriye
dc.institutionauthorYılmaz, Murat
dc.language.isoenen_US
dc.publisherAssoc Medica Brasileiraen_US
dc.relation.ispartofRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGullian-Barre Syndromeen_US
dc.subjectCytokinesen_US
dc.subjectInterleucinasen_US
dc.subjectInterleukin-17en_US
dc.subjectInterleukin-34en_US
dc.titleA comparison of IL-17 and IL-34 concentrations in the cerebrospinal fluid of patients with acute inflammatory demyelinating neuropathy and chronic inflammatory demyelinating polyneuropathyen_US
dc.typeArticleen_US

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