Comparison of the effect of teicoplanin and vancomycin on experimental methicillin-resistant staphylococcus aureus keratitis

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dc.authorid0000-0001-9945-793Xen_US
dc.authorid0000-0002-5676-6983
dc.contributor.authorÜçgül, Ahmet Yücel
dc.contributor.authorBehçet, Mustafa
dc.date.accessioned2021-06-23T19:17:07Z
dc.date.available2021-06-23T19:17:07Z
dc.date.issued2021
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractPurpose To evaluate the early efficacy and safety of intrastromal injection of teicoplanin as the alternative treatment for the methicillin-resistant Staphylococcus aureus (MRSA) keratitis by comparing it with vancomycin. Materials and methods Twenty-four eyes of 24 New Zealand white rabbits were included in the study. MRSA keratitis was induced in the right eye of each rabbit by injecting 0.1 mL MRSA suspension containing 1000 colony-forming units (CFU) intrastromally to the central cornea. The rabbits were divided into three treatment groups 24 h after the inoculation of MRSA. Eight rabbits received intrastromal teicoplanin therapy, eight received intrastromal vancomycin therapy, and eight received balanced salt solution and served as the control group. Nine hours after the treatment, all rabbits were sacrificed and corneal tissues were collected for microbiological analysis. We also examined and scored all the rabbits clinically before and after the treatment. Results The control group scored higher with regard to conjunctival injection, iritis, fibrin, hypopyon, epithelial erosion, and corneal infiltrate than the vancomycin and teicoplanin groups (p = 0.031, 0.010, < 0.001, 0.029, 0.009, and < 0.001, respectively). Chemosis and corneal oedema were similar in all groups (p = 0.731 and 0.075, respectively). The severity of all clinical parameters was similar in both the vancomycin and teicoplanin groups after the treatment. The bacterial load was the highest (7.83 +/- 0.71 log(10) CFU/g) in the control group. The eyes treated with vancomycin and teicoplanin had similar bacterial loads (6.40 +/- 0.69 vs. 6.31 +/- 0.75 log(10) CFU/g, p = 0.809). Conclusion The efficiency of teicoplanin seems to be comparable to that of vancomycin when administered intrastromally in the early treatment of MRSA keratitis. The former may be preferred in the treatment of selected cases with vancomycin hypersensitivity or resistance.en_US
dc.identifier.doi10.1007/s10792-021-01696-2
dc.identifier.endpage1402
dc.identifier.issn0165-5701
dc.identifier.issue4
dc.identifier.pmid33506369en_US
dc.identifier.scopus2-s2.0-85099861218en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1395
dc.identifier.urihttps://doi.org/10.1007/s10792-021-01696-2
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5222
dc.identifier.volume41
dc.identifier.wosWOS:000612246500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÜçgül, Ahmet Yücel
dc.institutionauthorBehçet, Mustafa
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKeratitisen_US
dc.subjectMethicillin-resistant Staphylococcus Aureusen_US
dc.subjectTeicoplaninen_US
dc.subjectVancomycinen_US
dc.titleComparison of the effect of teicoplanin and vancomycin on experimental methicillin-resistant staphylococcus aureus keratitisen_US
dc.typeArticleen_US

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