A rare non-hemolytic case of idiopathic cold agglutinin disease

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dc.authorid0000-0001-7306-5233en_US
dc.contributor.authorErkuş, Edip
dc.contributor.authorKoçak, Mehmet Zahid
dc.contributor.authorAktaş, Gülali
dc.contributor.authorÖzen, Mehmet
dc.contributor.authorAtak, Burçin Meryem
dc.contributor.authorDuman, Tuba T.
dc.contributor.authorTekçe, Buket Kın
dc.contributor.authorŞavlı, Haluk
dc.date.accessioned2021-06-23T19:50:13Z
dc.date.available2021-06-23T19:50:13Z
dc.date.issued2018
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Cold agglutinin disease is a very rare condition associated with agglutination of erythrocytes in cold environment usually due to IgM type antibodies. Other than hemolytic anemias, it may interfere with routine hemogram tests due to miscalculation of red blood cell count (RBC) and other hemogram parameters calculated with involvement of RBC. Awareness of the condition is important to overcome laboratory errors. Methods: We studied a peripheral blood smear and repeated the hemogram test at 37 degrees C to establish the diagnosis of cold agglutinin disease. Results: Initial hemogram test results of the fifty-eight year-old man was as follows: RBC: 1.34 M/jiL, hemoglobin (Hb): 12.4 g/dL, hematocrit (Htc): 11.8%, mean corpuscular hemoglobin (MCH): 92.4 pg, and mean corpuscular hemoglobin concentration (MCHC): 105 gr/dL. Despite the standard indirect Coombs test being negative, repeated tests at room temperature was 4+. We suspected cold agglutinin disease and repeated the hemogram test using the Bain-Marie method at 37 degrees C and the test results showed RBC: 3.4 M/mu L, hemoglobin: 12.6 g/dL, hematocrit: 30.2%, MCH: 31.7 pg, and MCHC: 41.8 g/dL. Conclusions: Inappropriate hemogram results may be a sign of underlying cold agglutinin disease. Hemolytic anemia not always accompanies the disease; however, cold exposure may trigger erythrocyte agglutination in vitro and may cause erratic laboratory results.en_US
dc.identifier.doi10.7754/Clin.Lab.2018.180114
dc.identifier.endpage1078en_US
dc.identifier.issn1433-6510
dc.identifier.issue6en_US
dc.identifier.pmid29945320en_US
dc.identifier.scopus2-s2.0-85049126311en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1075en_US
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2018.180114
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9729
dc.identifier.volume64en_US
dc.identifier.wosWOS:000441423200025en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAktaş, Gülali
dc.institutionauthorŞavlı, Haluk
dc.language.isoenen_US
dc.publisherClin Lab Publen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCold Agglutinin Diseaseen_US
dc.subjectRed Blood Cellen_US
dc.subjectHemogramen_US
dc.subjectIndirect Coombsen_US
dc.titleA rare non-hemolytic case of idiopathic cold agglutinin diseaseen_US
dc.typeArticleen_US

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