Glycated haemoglobin is correlated with the severity of coronary artery disease independently of traditional risk factors in young patients

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dc.authorid0000-0002-3156-1076en_US
dc.authorid0000-0002-1012-837X
dc.contributor.authorAyhan, S. Selim
dc.contributor.authorTosun, Mehmet
dc.contributor.authorÖztürk, Serkan
dc.contributor.authorAlçelik, Aytekin
dc.contributor.authorÖzlü, Mehmet Fatih
dc.contributor.authorErdem, Alim
dc.contributor.authorErdem, Kemalettin
dc.contributor.authorYazıcı, Mehmet
dc.date.accessioned2021-06-23T19:29:11Z
dc.date.available2021-06-23T19:29:11Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: In this study, we aimed to investigate the relationship between glycated haemoglobin (HbA(1c)) levels and the severity of coronary artery disease (CAD) in <40 years old patients. Material and methods: The study population consisted of 211 premature coronary atherosclerotic patients (pCAP) (aged 36.4 +/- 2.5 years) and 160 control subjects (36.4 +/- 2.4 years). The severity of CAD was evaluated by the Gensini scoring system. HbA(1c) levels and the other basic biochemical parameters were analysed, and relations with severity of CAD were evaluated. Results: There were statistically significant differences in serum HbA(1c) levels between the two groups (pCAP = 6.1 +/- 1.8%, control = 4.7 +/- 1.2%, p < 0.001). HbA(1c) levels significantly positively correlated with the Gensini score in pCAP (r = 0.662, p < 0.001). In linear multivariate regression analysis (including age, sex, HbA(1c), smoking, diabetes mellitus and hypertension as dependent parameters), only HbA(1c) was found to be an independent risk factor for the presence of severe CAD (Beta = 0.374, p < 0.001). In ROC curve analysis, the optimal cut-off value of HbA(1c) to predict severe CAD was 6.52%, with 74.4% sensitivity and 75.1% specificity (area under the curve 0.781, 95% confidence interval 0.661 to 0.901, p < 0.001). Conclusions: HbA(1c) levels were found to be correlated with the Gensini score in pCAP with and without diabetes. In this respect, glucose metabolism abnormalities, indicated by HbA(1c), may play an important role in premature CAD. (Endokrynol Pol 2012; 63 (5): 367- 371)en_US
dc.identifier.endpage371en_US
dc.identifier.issn0423-104X
dc.identifier.issue5en_US
dc.identifier.pmid23115070en_US
dc.identifier.startpage367en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7131
dc.identifier.urihttps://journals.viamedica.pl/endokrynologia_polska/article/view/25148
dc.identifier.volume63en_US
dc.identifier.wosWOS:000312018800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAyhan, S. Selim
dc.institutionauthorTosun, Mehmet
dc.institutionauthorÖztürk, Serkan
dc.institutionauthorAlçelik, Aytekin
dc.institutionauthorÖzlü, Mehmet Fatih
dc.institutionauthorErdem, Alim
dc.institutionauthorYazıcı, Mehmet
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofEndokrynologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlycated Haemoglobinen_US
dc.subjectPremature Coronary Artery Diseaseen_US
dc.subjectGensini Scoreen_US
dc.titleGlycated haemoglobin is correlated with the severity of coronary artery disease independently of traditional risk factors in young patientsen_US
dc.typeArticleen_US

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