The association of obesity and obesity-related conditions with carotid extra-medial thickness in children and adolescents

Basit Öğe Kaydı
dc.authorid0000-0003-2469-9509en_US
dc.authorid0000-0001-7778-1114
dc.authorid0000-0002-3802-0336
dc.authorid0000-0002-0202-8555
dc.contributor.authorBekdaş, Mervan
dc.contributor.authorKaya, E.
dc.contributor.authorDağıstan, Emine
dc.contributor.authorGöksügür, Sevil Bilir
dc.contributor.authorDemircioğlu, Fatih
dc.contributor.authorErkoçoğlu, Mustafa
dc.contributor.authorDilek, Mustafa
dc.date.accessioned2021-06-23T19:42:47Z
dc.date.available2021-06-23T19:42:47Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Carotid extra-medial thickness (EMT) and carotid intima-media thickness (cIMT) provide information concerning vascular changes. Objectives: In this study, we aimed to evaluate the association between carotid EMT and obesity and its metabolic complications in children. Methods: The study included 38 obese subjects and 30 age-matched and sex-matched healthy controls aged between 7 and 17 years. For all subjects, complete blood count, fasting blood glucose, serum insulin, aspartate aminotransferase, alanine aminotransferase, HDL cholesterol, total cholesterol and triglyceride levels were measured. The carotid EMT and cIMT were measured by an expert radiologist in all patients. Results: Body mass index (BMI) (28.8 +/- 3 vs. 18.1 +/- 2.2, p<0.001), total cholesterol (167.9 +/- 34.8 mg dL(-1) vs. 150.5 +/- 28.1 mg dL(-1), p = 0.029), homeostatic model assessment of insulin resistance (HOMA-IR) (4.3 vs. 1.7, p<0.001), cIMT (0.51 +/- 0.08 mm vs. 0.45 +/- 0.06 mm, p<0.001) and carotid EMT (0.74 +/- 0.11 mm vs. 0.64 +/- 0.1 mm, p<0.001) were significantly higher in obese subjects than in controls, while HDL cholesterol (41.6 +/- 6.5 mg dL(-1) vs. 49.5 +/- 7.5 mg dL(-1), p<0.001) was lower in obesity group. Among the obese subjects, the HOMA-IR values (4.7 vs. 3.6, p = 0.027), cIMT (0.54 +/- 0.07 mm vs. 0.49 +/- 0.07 mm, p = 0.039) and carotid EMT (0.79 +/- 0.1 mm vs. 0.7 +/- 0.1 mm, p=0.013) were significantly higher in postpubertal children compared with prepubertal children. BMI, cut-off values of HOMA-IR and cIMT were significantly associated with increased carotid EMT (p<0.001, p = 0.023 and p<0.001, respectively). The only independent risk factor affecting carotid EMT was BMI (p<0.001). Conclusion: We have found that carotid EMT is associated with cIMT, obesity and insulin resistance and the assessment of carotid EMT may provide additional information concerning early vascular disease.en_US
dc.identifier.doi10.1111/ijpo.12096
dc.identifier.endpage527en_US
dc.identifier.issn2047-6310
dc.identifier.issn2047-6302
dc.identifier.issue6en_US
dc.identifier.pmid26667397en_US
dc.identifier.scopus2-s2.0-84950265656en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage521en_US
dc.identifier.urihttps://doi.org/10.1111/ijpo.12096
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8607
dc.identifier.volume11en_US
dc.identifier.wosWOS:000390032800016en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBekdaş, Mervan
dc.institutionauthorDağıstan, Emine
dc.institutionauthorDilek, Mustafa
dc.institutionauthorErkoçoğlu, Mustafa
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Obesityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarotid Extra-Medial Thicknessen_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.subjectChilden_US
dc.subjectObesityen_US
dc.titleThe association of obesity and obesity-related conditions with carotid extra-medial thickness in children and adolescentsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
mervan-bekdas.pdf
Boyut:
153.03 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam metin / Full text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu