The association of obesity and obesity-related conditions with carotid extra-medial thickness in children and adolescents
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Carotid extra-medial thickness (EMT) and carotid intima-media thickness (cIMT) provide information concerning vascular changes. Objectives: In this study, we aimed to evaluate the association between carotid EMT and obesity and its metabolic complications in children. Methods: The study included 38 obese subjects and 30 age-matched and sex-matched healthy controls aged between 7 and 17 years. For all subjects, complete blood count, fasting blood glucose, serum insulin, aspartate aminotransferase, alanine aminotransferase, HDL cholesterol, total cholesterol and triglyceride levels were measured. The carotid EMT and cIMT were measured by an expert radiologist in all patients. Results: Body mass index (BMI) (28.8 +/- 3 vs. 18.1 +/- 2.2, p<0.001), total cholesterol (167.9 +/- 34.8 mg dL(-1) vs. 150.5 +/- 28.1 mg dL(-1), p = 0.029), homeostatic model assessment of insulin resistance (HOMA-IR) (4.3 vs. 1.7, p<0.001), cIMT (0.51 +/- 0.08 mm vs. 0.45 +/- 0.06 mm, p<0.001) and carotid EMT (0.74 +/- 0.11 mm vs. 0.64 +/- 0.1 mm, p<0.001) were significantly higher in obese subjects than in controls, while HDL cholesterol (41.6 +/- 6.5 mg dL(-1) vs. 49.5 +/- 7.5 mg dL(-1), p<0.001) was lower in obesity group. Among the obese subjects, the HOMA-IR values (4.7 vs. 3.6, p = 0.027), cIMT (0.54 +/- 0.07 mm vs. 0.49 +/- 0.07 mm, p = 0.039) and carotid EMT (0.79 +/- 0.1 mm vs. 0.7 +/- 0.1 mm, p=0.013) were significantly higher in postpubertal children compared with prepubertal children. BMI, cut-off values of HOMA-IR and cIMT were significantly associated with increased carotid EMT (p<0.001, p = 0.023 and p<0.001, respectively). The only independent risk factor affecting carotid EMT was BMI (p<0.001). Conclusion: We have found that carotid EMT is associated with cIMT, obesity and insulin resistance and the assessment of carotid EMT may provide additional information concerning early vascular disease.
Açıklama
Anahtar Kelimeler
Carotid Extra-Medial Thickness, Carotid Intima-Media Thickness, Child, Obesity
Kaynak
Pediatric Obesity
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
11
Sayı
6
