The comparison of dexmedetomidine and midazolam used for sedation of patients during upper endoscopy: A prospective, randomized study

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dc.authorid0000-0002-1441-6360en_US
dc.contributor.authorDemiraran, Yavuz
dc.contributor.authorKorkut, Esin
dc.contributor.authorTamer, Ali
dc.contributor.authorYorulmaz, İlknur
dc.contributor.authorKocaman, Buket
dc.contributor.authorSezen, Gülbin
dc.contributor.authorAkcan, Yusuf
dc.date.accessioned2021-06-23T19:20:39Z
dc.date.available2021-06-23T19:20:39Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractThe aim of the present prospective, randomized study was to investigate and compare the safety and efficacy of dexmedetomidine versus midazolam in providing sedation for gastroscopy. A total of 50 adult patients (25 patients receiving dexmedetomidine and 25 patients receiving midazolam), 18 to 60 years of age, and rated I and II on the American Society of Anesthesiologists physical status classification system were included. A brief questionnaire was used to collect demographic data; patients were asked to rate anxiety, satisfaction wit care to data and expected discomfort on a visual analogue scale. The following parameters were measured continuously and recorded every minute; heart rate, mean arterial pressure, hemoglobin oxygen saturation and respiratory rate. The two groups were similar with regard to age, body mass index, sex, education, duration of endoscopy, and ethanol or tobacco use. After the procedure, full recovery time, mean arterial pressure, heart rate, respiratory rate and hemoglobin oxygen saturation levels were similar in both groups. Both groups also had low levels of perceived procedural gagging, discomfort and anxiety scores (P > 0.05), and high satisfaction levels (90.1+/-3.0 for dexmedetomidine versus 84.9+/-4.5 for midazolam; P>0.05). Retching and endoscopist satisfaction were significantly different in patient receiving dexmedetomidine versus those receiving midazolam (88.8+/-6.5 versus 73.5+/-16.4, P<0.05; and 20.6+/-4.4 versus 45.2+/-6.0; P<0.001). In the midazolam group, the number of patients who had adverse effects was higher than the dexmedetomidine group (P<0.05). As a result, dexmedetomidine performed as effectively and safely as midazolam when used as a sedative in upper gastroscopy; it was superior to midazolam with regard to retching, rate of side effects and endoscopist satisfaction. It was concluded that dexmedetomidine may be a good alternative to midazolam to sedate patients for upper endoscopy.en_US
dc.identifier.doi10.1155/2007/350279
dc.identifier.endpage29en_US
dc.identifier.issn2291-2797
dc.identifier.issue1en_US
dc.identifier.pmid17225879en_US
dc.identifier.scopus2-s2.0-33847148422en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.1155/2007/350279
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6147
dc.identifier.volume21en_US
dc.identifier.wosWOS:000243835300004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDemiraran, Yavuz
dc.institutionauthorKorkut, Esin
dc.institutionauthorTamer, Ali
dc.institutionauthorYorulmaz, İlknur
dc.institutionauthorKocaman, Buket
dc.institutionauthorSezen, Gülbin
dc.institutionauthorAkcan, Yusuf
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofCanadian Journal Of Gastroenterology And Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectEndoscopyen_US
dc.subjectMidazolamen_US
dc.subjectSedationen_US
dc.titleThe comparison of dexmedetomidine and midazolam used for sedation of patients during upper endoscopy: A prospective, randomized studyen_US
dc.typeArticleen_US

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