The association between thyroid malignancy and chronic lymphocytic thyroiditis: should it alter the surgical approach?

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dc.authorid0000-0001-5366-2292
dc.authorid0000-0001-8540-1935
dc.authorid0000-0002-5181-1773
dc.contributor.authorBüyükaşık, Oktay
dc.contributor.authorHasdemir, Ahmet Oğuz
dc.contributor.authorYalçın, Erol
dc.contributor.authorCelep, Bahadır
dc.contributor.authorŞengül, Serkan
dc.contributor.authorAlkoy, Seval
dc.contributor.authorÇöl, Cavit
dc.date.accessioned2021-06-23T19:27:55Z
dc.date.available2021-06-23T19:27:55Z
dc.date.issued2011
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: The relation between thyroid neoplasms and chronic lymphocytic thyroiditis (CLT) is controversial. While it is accepted that focal lymphocytic thyroiditis develops secondarily to malignancy, it is not clear whether diffuse lymphocytic thyroiditis has a tendency to develop into thyroid cancer. The aim of this study was to investigate the relation between CLT and malignant tumours of the thyroid and evaluate the surgical approach to CLT cases. Material and methods: In this study, 917 patients operated on for thyroid diseases were investigated retrospectively. Seventy-seven (8.4%) patients histopathologically diagnosed as having CLT (either non-specific or Hashimoto's thyroiditis) were investigated for any concurrent malignant neoplasm. Fifteen patients in whom CLT and thyroid malignancy were coexisting were included in the study. Results: In the pathological evaluation of 917 cases, malignancy in the thyroid was found in 97 (10.6%) cases. Seventy-seven cases were categorised as CLT. Of these 77, 16(20.8%) were Hashimoto's thyroiditis (specific CLT) and the other 61(79.2%) were non-specific CLT. In 15 cases, thyroid malignancy was found to be concurrent with CLT. Of the malignities, nine (60%) were papillary carcinoma, three (20%) medullar carcinoma, one (6.6%) follicular carcinoma, one (6.6%) Hurthle cell carcinoma, and one (6.6%) lymphoma. In our series, the rate of the development of malignancy against the background of CLT was 19.48%, while the rate in the groups without CLT was 9.76%, with a statistically significant difference between the groups (p = 0.008). Conclusions: CLT cases should be evaluated more carefully in terms of malignancy. If a nodule is detected on thyroiditis, the minimal surgical intervention should be lobectomy. Total thyroidectomy should be considered as preferable to subtotal thyroidectomy because of its many advantages such as controlling thyroiditis, removing the probability of reoperation, and hormonal stability. (Pol J Endocrinol 2011; 62 (4): 303-308)en_US
dc.identifier.endpage308en_US
dc.identifier.issn0423-104X
dc.identifier.issue4en_US
dc.identifier.pmid21879469en_US
dc.identifier.scopus2-s2.0-80052581218en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage303en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6919
dc.identifier.urihttps://journals.viamedica.pl/endokrynologia_polska/article/view/25253
dc.identifier.volume62en_US
dc.identifier.wosWOS:000296548000004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBüyükaşık, Oktay
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofEndokrynologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThyroid Canceren_US
dc.subjectThyroiditisen_US
dc.subjectSurgeryen_US
dc.titleThe association between thyroid malignancy and chronic lymphocytic thyroiditis: should it alter the surgical approach?en_US
dc.typeArticleen_US

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