An experimental study on effects of pyrrolidine dithiocarbamate on ischemia-reperfusion injury in testis

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dc.authorid0000-0002-4242-9134en_US
dc.authorid0000-0003-1698-8263
dc.authorid0000-0002-8317-7092
dc.authorid0000-0002-4313-8478
dc.authorid0000-0001-7858-0672
dc.contributor.authorKemahlı, Eray
dc.contributor.authorYıldız, Mevlüt
dc.contributor.authorFırat, Tülin
dc.contributor.authorÖzyalvaçlı, Mehmet Emin
dc.contributor.authorÜyetürk, Uğur
dc.contributor.authorYılmaz, Burak
dc.contributor.authorGücük, Adnan
dc.date.accessioned2021-06-23T19:43:46Z
dc.date.available2021-06-23T19:43:46Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractIntroduction: The aim of this experimental study was to investigate the histopathological and biochemical effects of pyrrolidine dithiocarbamate, an antioxidant and inhibitor of NF-k beta, on ischemia-reperfusion injury in rats. Methods: A total of 21 male Wistar-Albino rats were randomly distributed into three groups as sham group (Group 1), ischemia-reperfusion (I/R) group (Group 2) and I/R with pyrrolidine dithiocarbamate (PDTC) group (Group 3). Left testicles of rats in Groups 2 and 3 underwent testicular torsion of 720 degrees for four hours and 100 mg/kg of PDTC was administered intraperitoneally prior to detorsion in Group 3. An hour after detorsion process, left orchiectomies were performed and 5 ml of intracardiac blood samples were drawn from rats in all three groups. Histopathological examination of testis tissues performed and measurement of superoxide dismutase (SOD) and malondialdehyde (MDA) levels in blood samples were taken. Results: Elevated levels of MDA and decreased SOD activity, together with decreased Johnson tubular biopsy scores consistent with I/R injury were observed in Group 2 (p<0.05). Group 1 and Group 3 were similar in terms of MDA levels, SOD activity, and Johnson scores (p>0.05). Conclusions: Our results indicated that PDTC may have beneficial effects for alleviation of I/R injury in testicular tissue in rats. Understanding the underlying mechanisms and exploration of its diagnostic and therapeutic potential requires further randomized, controlled trials on a larger scale.en_US
dc.identifier.doi10.5489/cuaj.3160
dc.identifier.endpageE109en_US
dc.identifier.issn1911-6470
dc.identifier.issn1920-1214
dc.identifier.issue3-4en_US
dc.identifier.pmid27330576en_US
dc.identifier.scopus2-s2.0-84960804867en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE104en_US
dc.identifier.urihttps://doi.org/10.5489/cuaj.3160
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8848
dc.identifier.volume10en_US
dc.identifier.wosWOS:000376732700005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKemahlı, Eray
dc.institutionauthorFırat, Tülin
dc.institutionauthorÖzyalvaçlı, Mehmet Emin
dc.institutionauthorÜyetürk, Uğur
dc.institutionauthorYılmaz, Burak
dc.institutionauthorGücük, Adnan
dc.language.isoenen_US
dc.publisherCanadian Urological Associationen_US
dc.relation.ispartofCuaj-Canadian Urological Association Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTestisen_US
dc.subjectPyrrolidine Dithiocarbamate
dc.subjectReperfusion Injury
dc.subjectRats
dc.titleAn experimental study on effects of pyrrolidine dithiocarbamate on ischemia-reperfusion injury in testisen_US
dc.typeArticleen_US

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