A new model of reversible obstructive jaundice using rapidly absorbable suture materials

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dc.authorid0000-0002-1426-0247
dc.contributor.authorKahramansoy, Nurettin
dc.contributor.authorErkol, Mehmet Hayri
dc.contributor.authorYılmaz, Edip E.
dc.contributor.authorŞit, Mustafa
dc.contributor.authorYılmaz, Fahri
dc.contributor.authorTosun, Mehmet
dc.contributor.authorÇöl, Cavit
dc.date.accessioned2021-06-23T19:33:56Z
dc.date.available2021-06-23T19:33:56Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: Reversible obstructive jaundice models have some limiting features, including the need for a second anaesthesia, re-laparotomy and surgical intervention after common bile duct ligation. The present study investigates the feasibility of a new application that can eliminate these limitations. Rapidly absorbable suture materials were used for ligation; therefore, spontaneous biliary decompression was anticipated by the self release of these rapidly degrading materials. Methods: Common bile ducts in Wistar Albino rats were ligated with silk, polyglytone 6211, or irradiated polyglactine 910 (n=7 for each group). Rats were grouped according to both the suture materials and the experiments termination date: 5 days (sham, silk5, polyglytone5, polyglactine5) and 21 days (silk21, polyglytone21, polyglactine21) after the ligation. Biochemical and morphologic changes of liver were assessed. Results: The group polyglactine21 showed significantly lower mean ALT, AST, GGT, total and direct bilirubin values when compared with the group polyglactine5 (p=0.004-0.037). Morphologic changes did not correlate with the biochemical amelioration. In the group polyglytone21, not only the biochemical but also the morphologic changes significantly ameliorated when compared with the group polyglytone5 (p=0.003-0.043). No procedure associated mortality was observed. Conclusion: Common bile duct ligation with polyglytone offers a new reversible model for prolonged obstructive jaundice which abolishes the need for re-laparotomy and a second surgical intervention and significantly reduces mortality.en_US
dc.identifier.endpageE357en_US
dc.identifier.issn0147-958X
dc.identifier.issue6en_US
dc.identifier.pmid23217560en_US
dc.identifier.scopus2-s2.0-84872463237en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageE351en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7291
dc.identifier.urihttps://search.ebscohost.com/login.aspx?direct=true&db=asn&AN=86194971&lang=tr&site=eds-live
dc.identifier.volume35en_US
dc.identifier.wosWOS:000314228700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKahramansoy, Nurettin
dc.institutionauthorErkol, Mehmet Hayri
dc.institutionauthorŞit, Mustafa
dc.institutionauthorYılmaz, Fahri
dc.institutionauthorÇöl, Cavit
dc.institutionauthorTosun, Mehmet
dc.institutionauthorYılmaz, Edip E.
dc.language.isoenen_US
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical And Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleA new model of reversible obstructive jaundice using rapidly absorbable suture materialsen_US
dc.typeArticleen_US

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