Serum and aqueous xanthine oxidase levels, and mRNA expression in anterior lens epithelial cells in pseudoexfoliation

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dc.authorid0000-0001-8707-4034en_US
dc.authorid0000-0003-1657-9099en_US
dc.contributor.authorSimavlı, Hüseyin
dc.contributor.authorTosun, Mehmet
dc.contributor.authorBucak, Yasin Yücel
dc.contributor.authorErdurmuş, Mesut
dc.contributor.authorOcak, Zeynep
dc.date.accessioned2021-06-23T19:42:01Z
dc.date.available2021-06-23T19:42:01Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of this study was to determine serum and aqueous xanthine oxidase (XO) levels, and mRNA expression in anterior lens epithelial cells in pseudoexfoliation (PEX). In this prospective study, serum, aqueous and anterior lens capsules were taken from 21 patients with PEX and 23 normal subjects who had undergone routine cataract surgery. Serum and aqueous XO levels were analyzed using the colorimetric method. mRNA expression of XO in anterior lens epithelial cells was evaluated using reverse transcription polymerase chain reaction analysis. Serum XO levels (means +/- standard deviations) were 207.0 +/- 86.1 IU/mL and 240.6 +/- 114.1 IU/mL in the normal and PEX groups, respectively (p = 0.310). Aqueous XO levels (means +/- standard deviations) were 65.5 +/- 54.3 IU/mL in the normal group and 130.5 +/- 117.4 IU/mL in the PEX group (p = 0.028). There was a 2.9 fold decrease in mRNA expression in anterior lens epithelial cells of PEX, which is significantly lower than the normal group (p = 0.01). Higher aqueous XO levels lacking associated different serum XO suggests higher oxidative stress in the aqueous. Higher aqueous XO levels in PEX with decreased mRNA expression in anterior lens epithelial cells indicate possible overexpression of XO in other structures related to the aqueous.en_US
dc.identifier.doi10.1007/s00417-015-3043-x
dc.identifier.endpage1167en_US
dc.identifier.issn0721-832X
dc.identifier.issn1435-702X
dc.identifier.issue7en_US
dc.identifier.pmid25957764en_US
dc.identifier.scopus2-s2.0-84933178665en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1161en_US
dc.identifier.urihttps://doi.org/10.1007/s00417-015-3043-x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8296
dc.identifier.volume253en_US
dc.identifier.wosWOS:000356948400021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTosun, Mehmet
dc.institutionauthorOcak, Zeynep
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofGraefes Archive For Clinical And Experimental Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPseudoexfoliationen_US
dc.subjectXanthine Oxidaseen_US
dc.subjectOxidative Stressen_US
dc.subjectAnterior Lens Capsuleen_US
dc.subjectAqueous Humoren_US
dc.subjectmRNA Expressionen_US
dc.titleSerum and aqueous xanthine oxidase levels, and mRNA expression in anterior lens epithelial cells in pseudoexfoliationen_US
dc.typeArticleen_US

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