Topical vancomycin is more efficient than povidone-ıodine treatment in controlling bacterial growth in methicillin-resistant staphylococcus aureus keratitis model in rabbits

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dc.authorid0000-0003-3669-4377
dc.authorid0000-0003-1018-925X
dc.authorid0000-0001-5454-3113
dc.authorid0000-0002-5676-6983
dc.contributor.authorAlkan, Yunus
dc.contributor.authorKaymaz, Abdulgani
dc.contributor.authorBehçet, Mustafa
dc.contributor.authorBayrak, Abdullah
dc.date.accessioned2024-09-25T20:00:10Z
dc.date.available2024-09-25T20:00:10Z
dc.date.issued2024
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractPurpose: To evaluate the efficacy of topical vancomycin and povidone iodine (PI) application on methicillin-resistant Staphylococcus aureus (MRSA) keratitis model in rabbits. Methods: MRSA keratitis was induced by injecting 0.1 mL MRSA containing 1000 colony-forming units (CFU) into central cornea of right eyes of 24 New Zealand White rabbits. Animals were divided into four groups (n = 6): control (treated with balanced salt solution), 50 mg/mL topical vancomycin, 5% topical PI, and combination; examined before and after treatment, and corneal tissues were harvested for analysis at 9th hour of treatment. Results: Bacterial load was determined as: 7.63 +/- 0.82 log10 CFU/g in control group, 6.95 +/- 1.66 log10 CFU/g in PI group, 4.67 +/- 0.77 log10 CFU/g in combination group, and 4.33 +/- 0.71 log10 CFU/g in vancomycin group (p = 0.001). Median of total clinical score increased significantly from 7 [range: 5-8] to 11.5 [range: 11-15] (p = 0.001) in control group, did not change (6 [range: 5-8] to 7 [range: 5-7]; p = 0.695) in vancomycin group, increased significantly from 7 [range: 5-8] to 12.5 [range: 10-14] (p < 0.001) in PI group, increased significantly from 6.5 [range: 5-7] to 8 [range: 7-9] in combination group (p = 0.002). Post-treatment clinical scores for chemosis, conjunctival injection, iritis, hypopyon, epithelial erosion, and corneal infiltrate were significantly lower in vancomycin-treated groups compared to others (p < 0.05). In PI-treated groups, especially scores for chemosis, conjunctival injection, epithelial erosion and corneal infiltrate were significantly higher than vancomycin (p < 0.05). Conclusion: Topical vancomycin significantly inhibited bacterial growth in MRSA keratitis. However, PI was ineffective in controlling this growth; additionally, exerted toxic effect on ocular surface. When vancomycin was combined with PI, no additional increase in efficacy of treatment was detected compared to only vancomycin.en_US
dc.identifier.doi10.1080/02713683.2024.2349661
dc.identifier.endpage929en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue9en_US
dc.identifier.pmid38708825en_US
dc.identifier.scopus2-s2.0-85192229867en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage923en_US
dc.identifier.urihttps://doi.org/10.1080/02713683.2024.2349661
dc.identifier.urihttps://hdl.handle.net/20.500.12491/14116
dc.identifier.volume49en_US
dc.identifier.wosWOS:001214849400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBehçet, Mustafa
dc.institutionauthorKaymaz, Abdulgani
dc.institutionauthorid0000-0002-5676-6983
dc.institutionauthorid0000-0003-1018-925X
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectVancomycinen_US
dc.subjectPovidone-Iodineen_US
dc.subjectMethicillin-Resistant Staphylococcus Aureusen_US
dc.subjectKeratitisen_US
dc.subjectTreatmenten_US
dc.subjectEpithelial Erosion
dc.titleTopical vancomycin is more efficient than povidone-ıodine treatment in controlling bacterial growth in methicillin-resistant staphylococcus aureus keratitis model in rabbitsen_US
dc.typeArticleen_US

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