Comparison of microporous polysaccharide hemospheres and Ankaferd Blood Stopper in a rabbit epistaxis model

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dc.authorid0000-0002-6223-4254
dc.contributor.authorYurttaş, Veysel
dc.contributor.authorŞereflican, Murat
dc.contributor.authorTerzi, Elçin Hakan
dc.contributor.authorÖzyalvaçlı, Gülzade
dc.contributor.authorKazaz, Hasan
dc.date.accessioned2021-06-23T19:43:42Z
dc.date.available2021-06-23T19:43:42Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractThe aim of this study was to evaluate the histopathological impact, effectiveness, and safety of two hemostatic agents, Ankaferd Blood Stopper (ABS) and microporous polysaccharide hemospheres (MPH), in an experimental rabbit epistaxis model. Rabbits were randomly assigned, using a computerized random number generator, to the following three groups of six animals: group 1 (control, irrigated with saline); group 2 (ABS-treated); and group 3 (MPH-treated). In all groups, a standardized rabbit epistaxis model was used. Hemostasis time and extent of nasal bleeding were measured to compare the hemostatic effect of ABS and MPH among groups. Septums were removed for histopathological analysis, 7 days after the procedure. ABS reduced hemostasis time to 104.2 s and amount of bleeding to 20.5 mg. MPH reduced hemostasis time to 71.7 s and amount of bleeding to 11.5 mg. Mean bleeding time in wounds administered ABS and MPH was significantly shorter compared with wounds administered isotonic saline solution (p = 0.004). ABS and MPH application decreased bleeding significantly compared with the control group (p = 0.004). Bleeding time and amount in the MPH group was significantly reduced compared with the ABS group (p = 0.013 and p = 0.004, respectively). There was no significant difference in the histopathological evaluation results between the ABS, MPH, and control groups. Our data indicate that both ABS and MPH represent safe, effective, and fast-acting hemostatic agents in the management of epistaxis. MPH was more effective than ABS in terms of hemostasis time and amount of bleeding.en_US
dc.identifier.doi10.1007/s00405-015-3692-8
dc.identifier.endpage938en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue4en_US
dc.identifier.pmid26100031en_US
dc.identifier.scopus2-s2.0-84960392705en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage933en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-015-3692-8
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8835
dc.identifier.volume273en_US
dc.identifier.wosWOS:000372432500020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYurttaş, Veysel
dc.institutionauthorŞereflican, Murat
dc.institutionauthorTerzi, Elçin Hakan
dc.institutionauthorÖzyalvaçlı, Gülzade
dc.institutionauthorKazaz, Hasan
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives Of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnkaferd Blood Stopperen_US
dc.subjectMicroporous Polysaccharide Hemospheresen_US
dc.subjectEpistaxis Treatmenten_US
dc.subjectHistopathologyen_US
dc.titleComparison of microporous polysaccharide hemospheres and Ankaferd Blood Stopper in a rabbit epistaxis modelen_US
dc.typeArticleen_US

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