Serum hepcidin levels and iron metabolism in obese children with and without fatty liver : case-control study

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dc.authorid0000-0003-2469-9509en_US
dc.authorid0000-0002-0202-8555
dc.authorid0000-0001-7778-1114
dc.contributor.authorDemircioğlu, Fatih
dc.contributor.authorGörünmez, Gökhan
dc.contributor.authorDağıstan, Emine
dc.contributor.authorGöksügür, Sevil Bilir
dc.contributor.authorBekdaş, Mervan
dc.contributor.authorTosun, Mehmet
dc.contributor.authorKızıldağ, Betül
dc.date.accessioned2021-06-23T19:35:49Z
dc.date.available2021-06-23T19:35:49Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractHepcidin is a regulator of iron balance that is increased in obesity. It reduces the absorption of iron, reduces the transfer of iron from macrophages to the plasma and/or prevents mobilisation of stored iron. Obese patients with non-alcoholic fatty liver disease (NAFLD) demonstrate adipokine and cytokine release promoting inflammatory response. We aimed to analyse the hepcidin levels and iron metabolism in obese children with and without NAFLD and non-obese healthy controls. The study population consisted of 110 children aged 7-18 years in three groups: 50 obese patients without NAFLD, 30 obese patients with NAFLD, and 30 non-obese healthy controls. Serum hepcidin, ferritin, and iron levels, iron-binding capacity, lipid profile, and liver function tests were measured, and hepatic ultrasonography was performed in all participants. Obese patients' white blood cell counts, total cholesterol, triglyceride levels, and homeostatic model assessment of insulin resistance (HOMA-IR) were significantly higher than those of the control group. Iron-binding capacity was significantly higher in obese patients without NAFLD compared with obese patients with NAFLD (p = 0.002). Hepcidin levels were not significantly different between obese patients and the control group. However, hepcidin levels in obese patients with NAFLD were significantly higher than those in obese patients without NAFLD (p < 0.001). Conclusions: Hepcidin levels were significantly higher in obese children with NAFLD than those without NAFLD. Obese children with NAFLD should receive attention regarding iron metabolism disorders. Serum hepcidin could be a marker of iron metabolism status and NAFLD in these groups of patients.en_US
dc.identifier.doi10.1007/s00431-014-2268-8
dc.identifier.endpage951en_US
dc.identifier.issn0340-6199
dc.identifier.issn1432-1076
dc.identifier.issue7en_US
dc.identifier.pmid24500395en_US
dc.identifier.scopus2-s2.0-84903821106en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage947en_US
dc.identifier.urihttps://doi.org/10.1007/s00431-014-2268-8
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7871
dc.identifier.volume173en_US
dc.identifier.wosWOS:000338219600013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDemircioğlu, Fatih
dc.institutionauthorGörünmez, Gökhan
dc.institutionauthorDağıstan, Emine
dc.institutionauthorGöksügür, Sevil Bilir
dc.institutionauthorBekdaş, Mervan
dc.institutionauthorTosun, Mehmet
dc.institutionauthorKızıldağ, Betül
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal Of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFatty Liveren_US
dc.subjectObesityen_US
dc.subjectChildrenen_US
dc.subjectHepcidinen_US
dc.subjectIron Metabolismen_US
dc.titleSerum hepcidin levels and iron metabolism in obese children with and without fatty liver : case-control studyen_US
dc.typeArticleen_US

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