A novel inflammatory marker for the diagnosis of Hashimoto's thyroiditis: Platelet-count-to-lymphocyte-count ratio

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dc.authorid0000-0001-7455-8136en_US
dc.authorid0000-0002-3836-2125en_US
dc.authorid0000-0001-7306-5233en_US
dc.contributor.authorErge, Eray
dc.contributor.authorKızıltunç, Çağrı
dc.contributor.authorBalcı, Sümeyye Buse
dc.contributor.authorTel, Burçin Meryem Atak
dc.contributor.authorBilgin, Satılmış
dc.contributor.authorDuman, Tuba Taslamacıoğlu
dc.contributor.authorAktaş, Gülali
dc.date.accessioned2024-03-08T08:16:04Z
dc.date.available2024-03-08T08:16:04Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Hashimoto's thyroiditis (HT) is a chronic autoimmune thyroiditis that causes systemic inflammation in the body, leading to hypothyroidism and an enlargement of the thyroid gland. Objectives: This study aims to reveal whether there is a relationship between Hashimoto's thyroiditis and the platelet-count-to-lymphocyte-count ratio (PLR), which is used as a new inflammatory marker. Methods: In this retrospective study, we compared the PLR of the euthyroid HT group and the hypothyroid-thyrotoxic HT group to the controls. We also evaluated the values of thyroid-stimulating hormone (TSH), free T4 (fT4), C-reactive protein (CRP), aspartate transaminase (AST), alanine transaminase (ALT), white blood cell count, lymphocyte count, hemoglobin, hematocrit, and platelet count in each group. Results: The PLR of the subjects with Hashimoto's thyroiditis was found to be significantly different from the control group (p < 0.001), with the rankings as follows: hypothyroid-thyrotoxic HT 177% (72-417) > euthyroid HT 137% (69-272) > control group 103% (44-243). In addition to the increased PLR values, an increase in CRP values was also observed, revealing a strong positive correlation between the PLR and CRP in the HT patients. Conclusion: In this study, we found out that the PLR was higher in the hypothyroid-thyrotoxic HT and euthyroid HT patients than in a healthy control group.en_US
dc.identifier.citationErge, E., Kiziltunc, C., & Balci, S. B. A novel inflammatory marker for the diagnosis of hashimoto’s thyroiditis: platelet-count-to-lymphocyte-count ratio. Diseases 2023; 11: 15.en_US
dc.identifier.doi10.3390/diseases11010015
dc.identifier.endpage10en_US
dc.identifier.issn2079-9721
dc.identifier.issue1en_US
dc.identifier.pmid36810529en_US
dc.identifier.scopus2-s2.0-85158156243en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.3390/diseases11010015
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12070
dc.identifier.volume11en_US
dc.identifier.wosWOS:000955473300001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKızıltunç, Çağrı
dc.institutionauthorBalcı, Sümeyye Buse
dc.institutionauthorDuman, Tuba Taslamacıoğlu
dc.institutionauthorAktaş, Gülali
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofDiseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHashimoto's Thyroiditisen_US
dc.subjectInflammationen_US
dc.subjectPlatelet-To-Lymphocyte Ratioen_US
dc.subjectDiseaseen_US
dc.subjectThrombocytosisen_US
dc.subjectSuppressionen_US
dc.titleA novel inflammatory marker for the diagnosis of Hashimoto's thyroiditis: Platelet-count-to-lymphocyte-count ratioen_US
dc.typeArticleen_US

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