A novel inflammatory marker for the diagnosis of Hashimoto's thyroiditis: Platelet-count-to-lymphocyte-count ratio
Yükleniyor...
Dosyalar
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
MDPI
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Hashimoto's thyroiditis (HT) is a chronic autoimmune thyroiditis that causes systemic inflammation in the body, leading to hypothyroidism and an enlargement of the thyroid gland. Objectives: This study aims to reveal whether there is a relationship between Hashimoto's thyroiditis and the platelet-count-to-lymphocyte-count ratio (PLR), which is used as a new inflammatory marker. Methods: In this retrospective study, we compared the PLR of the euthyroid HT group and the hypothyroid-thyrotoxic HT group to the controls. We also evaluated the values of thyroid-stimulating hormone (TSH), free T4 (fT4), C-reactive protein (CRP), aspartate transaminase (AST), alanine transaminase (ALT), white blood cell count, lymphocyte count, hemoglobin, hematocrit, and platelet count in each group. Results: The PLR of the subjects with Hashimoto's thyroiditis was found to be significantly different from the control group (p < 0.001), with the rankings as follows: hypothyroid-thyrotoxic HT 177% (72-417) > euthyroid HT 137% (69-272) > control group 103% (44-243). In addition to the increased PLR values, an increase in CRP values was also observed, revealing a strong positive correlation between the PLR and CRP in the HT patients. Conclusion: In this study, we found out that the PLR was higher in the hypothyroid-thyrotoxic HT and euthyroid HT patients than in a healthy control group.
Açıklama
Anahtar Kelimeler
Hashimoto's Thyroiditis, Inflammation, Platelet-To-Lymphocyte Ratio, Disease, Thrombocytosis, Suppression
Kaynak
Diseases
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
11
Sayı
1
Künye
Erge, E., Kiziltunc, C., & Balci, S. B. A novel inflammatory marker for the diagnosis of hashimoto’s thyroiditis: platelet-count-to-lymphocyte-count ratio. Diseases 2023; 11: 15.
