Evaluation of emm gene types, toxin gene profiles and clonal relatedness of group A streptococci

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dc.authorid0000-0002-6220-0521en_US
dc.authorid0000-0003-3087-5425en_US
dc.authorid0000-0003-0727-1797
dc.authorid0000-0003-0161-6897
dc.contributor.authorMengeloğlu, Fırat Zafer
dc.contributor.authorAktaş, Elif
dc.contributor.authorOtlu, Barış
dc.contributor.authorCömert, Füsun
dc.contributor.authorKülah, Canan
dc.date.accessioned2021-06-23T19:34:21Z
dc.date.available2021-06-23T19:34:21Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of this study is to evaluate antibiotic susceptibilities, emm gene types, toxin gene profiles and clonal relatedness of group A streptococci (GAS) isolates obtained from patients and carriers. A total of 79 clinical isolates from patients and 60 isolates from carriers were included in the study. Emm typing, toxin gene detection for speA, speB, speC, speG and smeZ genes and pulsed-field gel electrophoresis (PFGE) was performed. Twenty-one distinct emm types were detected; the most common types were emm12, emm89, emm1, emm77, emm4 and emm3. The. detection rates of both emm types and the toxin genes didn't differ significantly between patients and carriers. The presence of speA and smeZ was significantly higher in emm1 and speG was significantly lower in emm4 when compared to the other emm types. The rate of clustering obtained with PFGE wasn't significantly different in patients and carriers. As a result, twelve of the 21 emm types detected in this study were covered by the 26-valent vaccine, constituting 77.7% of the emm typeable isolates; however the emm4 type which is one of the most common types in the present study is not among this coverage. (C) 2013 Association of Basic Medical Sciences of FB&H. All rights reserveden_US
dc.identifier.doi10.17305/bjbms.2013.2356
dc.identifier.endpage169en_US
dc.identifier.issn1512-8601
dc.identifier.issn1840-4812
dc.identifier.issue3en_US
dc.identifier.pmid23988167en_US
dc.identifier.scopus2-s2.0-84883643100en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage163en_US
dc.identifier.urihttps://doi.org/10.17305/bjbms.2013.2356
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7479
dc.identifier.volume13en_US
dc.identifier.wosWOS:000330925100006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMengeloğlu, Fırat Zafer
dc.language.isoenen_US
dc.publisherAssoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevoen_US
dc.relation.ispartofBosnian Journal Of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGroup A Streptococcien_US
dc.subjectEmm Typingen_US
dc.subjectToxin Genesen_US
dc.subjectSpeAen_US
dc.subjectSpeBen_US
dc.subjectSpeCen_US
dc.subjectClonal Relationen_US
dc.subjectPFGEen_US
dc.titleEvaluation of emm gene types, toxin gene profiles and clonal relatedness of group A streptococcien_US
dc.typeArticleen_US

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