Evaluation of emm gene types, toxin gene profiles and clonal relatedness of group A streptococci
Yükleniyor...
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of this study is to evaluate antibiotic susceptibilities, emm gene types, toxin gene profiles and clonal relatedness of group A streptococci (GAS) isolates obtained from patients and carriers. A total of 79 clinical isolates from patients and 60 isolates from carriers were included in the study. Emm typing, toxin gene detection for speA, speB, speC, speG and smeZ genes and pulsed-field gel electrophoresis (PFGE) was performed. Twenty-one distinct emm types were detected; the most common types were emm12, emm89, emm1, emm77, emm4 and emm3. The. detection rates of both emm types and the toxin genes didn't differ significantly between patients and carriers. The presence of speA and smeZ was significantly higher in emm1 and speG was significantly lower in emm4 when compared to the other emm types. The rate of clustering obtained with PFGE wasn't significantly different in patients and carriers. As a result, twelve of the 21 emm types detected in this study were covered by the 26-valent vaccine, constituting 77.7% of the emm typeable isolates; however the emm4 type which is one of the most common types in the present study is not among this coverage. (C) 2013 Association of Basic Medical Sciences of FB&H. All rights reserved
Açıklama
Anahtar Kelimeler
Group A Streptococci, Emm Typing, Toxin Genes, SpeA, SpeB, SpeC, Clonal Relation, PFGE
Kaynak
Bosnian Journal Of Basic Medical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
13
Sayı
3
