The effect of beta receptor blockade through propranolol on corneal neovascularization

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dc.authorid0000-0003-1657-9099en_US
dc.contributor.authorSimavlı, Hüseyin
dc.contributor.authorErdurmuş, Mesut
dc.contributor.authorTerzi, Elçin Hakan
dc.contributor.authorBucak, Yasin Yücel
dc.contributor.authorÖnder, Halil İbrahim
dc.contributor.authorKükner, Ahmet Şahap
dc.date.accessioned2021-06-23T19:35:28Z
dc.date.available2021-06-23T19:35:28Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: To evaluate the inhibitory effects of propranolol, a nonselective and lipophilic -adrenergic receptor blocker, on alkali-induced corneal neovascularization (NV). Methods: Corneal NV was induced in 24 eyes of 24 Wistar rats using NaOH. Following alkali burn, animals were randomized into 4 groups according to topical treatment. Group I received 0.9% NaCl, Group II received preservative-free dexamethasone sodium phosphate 1mg/mL, Group III received propranolol hydrochloride 1mg/mL, and Group IV received 0.5mg/mL propranolol hydrochloride drops twice a day for 7 days. The inhibitory effects of the drugs were compared as the percent areas of cornea covered by NV. Anti-vascular endothelial growth factor (VEGF) and anti-active caspase-3 immunostainings were also performed in corneal sections. Results: The median percent area of corneal NV was 59% (40.3-65.6) in Group I, 25.5% (20.9-43.4) in Group II, 68.9% (36.7-78.0) in Group III, and 50.4% (42.2-63.3) in Group IV. Group III and IV did not show any difference in comparison to Group I. Group II showed a statistically significant smaller area of corneal NV compared with Group I, III, and IV (P=0.004 for each comparison). Anti-VEGF immunostaining was significantly less in Group II compared with the other groups. Anti-active caspase-3 immunostaining was not different among the treatment groups. Conclusions: Topical propranolol 1 or 0.5mg/mL does not have a significant inhibitory effect on alkali-induced corneal NV in rats.en_US
dc.identifier.doi10.1089/jop.2013.0238
dc.identifier.endpage656en_US
dc.identifier.issn1080-7683
dc.identifier.issn1557-7732
dc.identifier.issue8en_US
dc.identifier.pmid24983781en_US
dc.identifier.scopus2-s2.0-84912003476en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage650en_US
dc.identifier.urihttps://doi.org/10.1089/jop.2013.0238
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7795
dc.identifier.volume30en_US
dc.identifier.wosWOS:000342560200007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorSimavlı, Hüseyin
dc.institutionauthorErdurmuş, Mesut
dc.institutionauthorTerzi, Elçin Hakan
dc.institutionauthorKükner, Ahmet Şahap
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofJournal Of Ocular Pharmacology And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleThe effect of beta receptor blockade through propranolol on corneal neovascularizationen_US
dc.typeArticleen_US

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