Determining immunoassay cutoff value using Western blot results to predict hepatitis C infection in blood donors with low-titer anti-HCV reactivity

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dc.authorid0000-0001-6133-9604en_US
dc.contributor.authorKüçükbayrak, Abdulkadir
dc.contributor.authorÇakmak, Saadet
dc.contributor.authorHakyemez, Ismail Necati
dc.contributor.authorTaş, Tekin
dc.contributor.authorAkdeniz, Hayrettin
dc.date.accessioned2021-06-23T19:34:26Z
dc.date.available2021-06-23T19:34:26Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractSince the 1990s, blood donors have been scanned for anti-hepatitis C virus (anti-HCV) antibodies, which can be defined by enzyme immunoassay as a screening test. In this population, false-reactive ratios have been high. Recently, some authors have aimed to find a cutoff value for anti-HCV different from those established by test manufacturers to predict HCV infection. In this study, 321 patients, after two repeating tests, had reactive results in s/co < 10 titers on anti-HCV test. The patients were 29.6 % (n=95) in women and 70.4 % (n=226) in men. The patients were classified into three groups by Western blot (WB) results (PS, positive; NG, negative; and ID, indeterminate). The average anti-HCV titer of the whole group was 2.61 +/- 1.96. Anti-HCV titers of subgroups were 2.43 +/- 1.95 in NG, 4.93 +/- 2.53 in PS, and 2.50 +/- 1.65 in ID (p< 0.001). There was a significant difference between NG and PS and between PS and ID subgroups (p< 0.001). There was a positive correlation between WB and anti-HCV titers in all patients (r=0.298, p< 0.001), in women (r=0.282, p< 0.001), and in men (r=0.337, p=0.002). According to receiver operator characteristic curve analysis, the cutoff value of anti-HCV titer to predict hepatitis C infection was > 2.61 s/co, with 74.1 % sensitivity and 71.6 % specificity (area under the curve, 0.820; 95 % confidence interval, 0.753 to 0.887). We suggest that an effective cutoff value for anti-HCV other than that established by the manufacturer cannot be assigned to predict hepatitis C infection for blood donors in low-prevalence areas.en_US
dc.identifier.doi10.1007/s12223-012-0215-5
dc.identifier.endpage347en_US
dc.identifier.issn0015-5632
dc.identifier.issn1874-9356
dc.identifier.issue4en_US
dc.identifier.pmid23208738en_US
dc.identifier.scopus2-s2.0-84879158117en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage343en_US
dc.identifier.urihttps://doi.org/10.1007/s12223-012-0215-5
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7514
dc.identifier.volume58en_US
dc.identifier.wosWOS:000322712700011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKüçükbayrak, Abdulkadir
dc.institutionauthorHakyemez, Ismail Necati
dc.institutionauthorTaş, Tekin
dc.institutionauthorAkdeniz, Hayrettin
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofFolia Microbiologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleDetermining immunoassay cutoff value using Western blot results to predict hepatitis C infection in blood donors with low-titer anti-HCV reactivityen_US
dc.typeArticleen_US

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