The condition of symmetrical sacroiliitis in axial spondyloarthritis: Comment on the article by Coates et al
Yükleniyor...
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
To the Editor:I read the article by Coates et al (1), recently published in Arthritis Care & Research, with great interest as it relates to the radiographic phenotype of axial spondyloarthritis according to the presence of HLA– B27, regardless of the primary diagno-sis of ankylosing spondylitis (AS) or psoriatic arthritis (PsA). The authors stated that the HLA– B27 gene is related to radiographic progression, syndesmophyte symmetry, and marginal syndes-mophytes, but not to sacroiliac symmetry. I would like to offer some suggestions from a biomechanical aspect, based on their important findings. Chronic biomechanical stress and microdam-age have been postulated as major triggering factors for lesion development, particularly in PsA. As compatible with a biome-chanical standpoint, tissue- specific kinetic factors (applied forces during motion) may play a critical role in the development of psori-atic lesions. Thus, PsA can de defined as an inflammatory disorder of more mobile musculoskeletal structures when AS is considered.
Açıklama
Anahtar Kelimeler
HLA– B27 Gene, Sacroiliac (SI), Joint
Kaynak
Arthritis Care & Research
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
73
Sayı
7
Künye
Tönük, Ş. B. (2021). The condition of symmetrical sacroiliitis in axial spondyloarthritis: comment on the article by Coates et al. Arthritis Care & Research, 73(7), 1055-1056.
