High asymmetric dimethylarginine (ADMA) levels in patients with Brucellosis

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dc.authorid0000-0001-8063-4836en_US
dc.authorid0000-0003-1930-6651
dc.authorid0000-0001-9919-6055
dc.contributor.authorMengeloğlu, Zafer
dc.contributor.authorSünnetçioğlu, Mahmut
dc.contributor.authorTosun, Mehmet
dc.contributor.authorKüçükbayrak, Abdülkadir
dc.contributor.authorCeylan, Mehmet Reşat
dc.contributor.authorAkdeniz, Hayrettin
dc.date.accessioned2021-06-23T19:36:23Z
dc.date.available2021-06-23T19:36:23Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAsymmetric dimethylarginine (ADMA) is the main endogenous inhibitor of nitric oxide synthase and is considered to be associated with endothelial dysfunction. Brucellosis, a zoonotic disease caused by Brucella spp., can manifest as vasculopathy. The present study was performed to investigate the relationship between ADMA and brucellosis. Serum samples from 39 patients with an accurate diagnosis of brucellosis and from 18 healthy control individuals were included in this study. ADMA levels were significantly higher in the patient group than the controls (P < 0.001). Receiver operating characteristic (ROC) curve analysis indicated that ADMA level a parts per thousand yen0.61 had a sensitivity of 79.5 %, specificity of 88.9 %, positive predictive value of 93.9 %, and negative predictive value of 66.7 %. This is the first report of an association between brucellosis and high levels of ADMA. In conclusion, ADMA levels should be tested in brucellosis cases and that further studies to clarify the mechanism underlying the association between ADMA and brucellosis are required.en_US
dc.identifier.doi10.1007/s10753-013-9720-1
dc.identifier.endpage131en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue1en_US
dc.identifier.pmid23978912en_US
dc.identifier.scopus2-s2.0-84900359823en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-013-9720-1
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7983
dc.identifier.volume37en_US
dc.identifier.wosWOS:000330849600016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMengeloğlu, Zafer
dc.institutionauthorTosun, Mehmet
dc.institutionauthorKüçükbayrak, Abdülkadir
dc.institutionauthorAkdeniz, Hayrettin
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectasymmetric dimethylarginineen_US
dc.subjectADMAen_US
dc.subjectBrucellosisen_US
dc.subjectBrucellaen_US
dc.titleHigh asymmetric dimethylarginine (ADMA) levels in patients with Brucellosisen_US
dc.typeArticleen_US

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