Evaluation of endothelial dysfunction in COVID-19 with flow-mediated dilatation

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dc.authorid0000-0002-1495-1697en_US
dc.authorid0000-0002-0465-8454en_US
dc.authorid0000-0003-2399-9585en_US
dc.authorid0000-0003-3817-851Xen_US
dc.contributor.authorMansıroğlu, Aslı Kurtar
dc.contributor.authorSeymen, Hande
dc.contributor.authorSincer, İsa
dc.date.accessioned2023-11-20T08:59:34Z
dc.date.available2023-11-20T08:59:34Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Inflammation is known to play a crucial role in many diseases, including COVID-19. Objective: Using flow-mediated dilatation (FMD), we aimed to assess the effects of inflammation on endothelial function in COVID-19 patients. Methods: This study was conducted with a total of 161 subjects, of whom 80 were diagnosed with COVID-19 within the last six months (comprising 48 women and 32 men with a mean age of 32.10 +/- 5.87 years) and 81 were healthy controls (comprising 45 women and 36 men with a mean age of 30.51 +/- 7.33 years). We analyzed the findings of transthoracic echocardiography and FMD in all subjects. All results were considered statistically significant at the level of p < 0.05. Results: The echocardiography and FMD of the COVID-19 group were performed 35 days (range: 25-178) after diagnosis. There was no statistically significant difference in echocardiographic parameters. Differently, FMD (%) was significantly higher in the control group (9.52 +/- 5.98 vs. 12.01 +/- 6.18, p=0.01). In multivariate analysis with the forward stepwise model, FMD was significantly different in the control group compared to the COVID-19 group (1.086 (1.026 - 1.149), p=0.04). A Spearman's correlation test indicated that FMD (r=0.27, p=0.006) had a weak positive correlation with the presence of COVID-19. Conclusion: Our findings point to COVID-19-induced endothelial dysfunction, as assessed by FMD, in the early recovery phase.en_US
dc.identifier.citationMansiroglu, A. K., Seymen, H., Sincer, I., & Gunes, Y. (2022). Evaluation of endothelial dysfunction in COVID-19 with flow-mediated dilatation. Arquivos Brasileiros de Cardiologia, 119, 319-325.en_US
dc.identifier.doi10.36660/abc.20210561
dc.identifier.endpage324en_US
dc.identifier.issn0066-782X
dc.identifier.issue2en_US
dc.identifier.pmid35674570en_US
dc.identifier.scopus2-s2.0-85135523579en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage319en_US
dc.identifier.urihttp://dx.doi.org/10.36660/abc.20210561
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11859
dc.identifier.volume119en_US
dc.identifier.wosWOS:000841701300019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorMansıroğlu, Aslı Kurtar
dc.institutionauthorSeymen, Hande
dc.institutionauthorSincer, İsa
dc.language.isoenen_US
dc.publisherArquivos Brasileiros Cardiologiaen_US
dc.relation.ispartofArquivos Brasileiros de Cardiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19/Complicationsen_US
dc.subjectEndothelialen_US
dc.subjectCells/infectionen_US
dc.subjectRisk-Factorsen_US
dc.subjectCoronavirusen_US
dc.subjectInflammationen_US
dc.titleEvaluation of endothelial dysfunction in COVID-19 with flow-mediated dilatationen_US
dc.typeArticleen_US

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