Pretreatment with stellate ganglion blockade before ischemia reduces infarct size in rat hearts

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dc.authorid0000-0001-5073-0691en_US
dc.authorid0000-0002-7527-4634
dc.authorid0000-0002-0363-9307
dc.authorid0000-0003-0582-8723
dc.contributor.authorGülcü-Bulut, Nebahat
dc.contributor.authorGonca, Ersöz
dc.contributor.authorKoçoğlu, Hasan
dc.contributor.authorBozdoğan, Ömer
dc.contributor.authorKaraaslan, Kazım
dc.date.accessioned2021-06-23T19:27:14Z
dc.date.available2021-06-23T19:27:14Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: To investigate the role of stellate ganglion blockade (SGB) in cardio-protection against ischemia reperfusion injury. Methods: This prospective randomized, experimental study was carried out between August and October 2008 in the Department of Anesthesia, Abant Izzet Baysal University, Bolu, Turkey. Twenty-one rats were randomly divided into 3 groups; group 1 - SGB group (rats with percutaneous ganglion blockade), group 2 - preconditioned (P) group (rats that were subjected to ischemia and then reperfusion periods for 5 minutes), and group 3 - control group (rats that were injected with normal saline). Results: During the ligation period, the length of arrhythmia was significantly shorter in group 2 compared with group 3 (p<0.001). The arrhythmia score in groups 1 and 2 was significantly lower compared with group 3 (p<0.001). In the reperfusion period, the length of arrhythmia was not significantly different in all study groups (p>0.05). But the arrhythmia score was significantly lower both in group 1 and group 3, compared with group 2 (p<0.02). Both in the ischemic and reperfusion periods, the incidence of arrhythmia was lowest in group I. The infarct size was measured significantly less in groups 1 and 2 compared with group 3 (p<0.001). Conclusion: Pretreatment with the left SGB leads to lower arrhythmia scores and reduced infarct size in the Langendorff-perfused rat hearts compared with group 3, but not with group 2.en_US
dc.identifier.endpage152en_US
dc.identifier.issn0379-5284
dc.identifier.issue2en_US
dc.identifier.pmid20174729en_US
dc.identifier.scopus2-s2.0-77949498179en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage148en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6766
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77949498179&partnerID=40&md5=a6aed57c2d9cb1a8eb38b922b72a5067
dc.identifier.volume31en_US
dc.identifier.wosWOS:000276937100006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGülcü-Bulut, Nebahat
dc.institutionauthorBozdoğan, Ömer
dc.institutionauthorKoçoğlu, Hasan
dc.institutionauthorKaraaslan, Kazım
dc.language.isoenen_US
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStellate Ganglion Blockaden_US
dc.titlePretreatment with stellate ganglion blockade before ischemia reduces infarct size in rat heartsen_US
dc.typeArticleen_US

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