Both mitochondrial K-ATP channel opening and sarcolemmal K-ATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats

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dc.authorid0000-0001-5073-0691en_US
dc.contributor.authorGonca, Ersöz
dc.contributor.authorBozdoğan, Ömer
dc.date.accessioned2021-06-23T19:26:42Z
dc.date.available2021-06-23T19:26:42Z
dc.date.issued2010
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractAim This study was performed to assess The effect of selective sarcolemmal adenosine tnphosphate (ATP)-sensitive K+ channel (K-ATP) inhibition and the mitochondnal K-ATP channel activation on ischemia and reperfusion (I/R)-induced arrhythmias in different gender of rats We compared the effect of a selective sarcolemmal K-TAP channel blocker HMR 1098, a selective mitochondrial K-ATP channel opener diazoxide, a nonselective K-ATP channel opener pinacidil, and the combination of pinacidil with HMR 1098 on the incidence and duration of ventricular arrhythmias in 2 groups anesthetized males (n = 31) and females (n = 31) Main Methods ischema and reperfusion was produced by occluding the left main coronary artery of Sprague-Dowley rats for 6 minutes followed by re-opening of the artery for 6 minutes Key Findings The arrhythmia score and the duration of arrhythmias were significantly reduced by HMR 1098, diazoxide, and pinacidil in male rats The combination of the pinacidil with HMR 1098 did not change the antiarrhythmic effect of pinacidil The duration of arrhythmas was shorter in females than that in the corresponding males Drug treatments were not effective in decreasing arrhythmias in female groups to the same extent as in the male group However, the mitochondrial K-ATP channel activation that is provided by the combination of pinacidil with HMR 1098 significantly decreased the total length of arrhythmias in females Significance Results of the current study indicate that both mitochondnal K-ATP channel activation and sarcolemmal K-ATP channel inhibition exert antiarrhythmic action in male rats The antiarrthythmic effect of pinacidil is not depend on the sarcolemmal K-ATP channel opening These results also indicate that K-ATP channel modulators show no discernable effect in female rats due to the already low incidence of arrhythmias in femalesen_US
dc.identifier.doi10.1177/1074248410372925
dc.identifier.endpage411en_US
dc.identifier.issn1074-2484
dc.identifier.issue4en_US
dc.identifier.pmid20693159en_US
dc.identifier.scopus2-s2.0-78651272152en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage403en_US
dc.identifier.urihttps://doi.org/10.1177/1074248410372925
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6627
dc.identifier.volume15en_US
dc.identifier.wosWOS:000284303300012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBozdoğan, Ömer
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofJournal Of Cardiovascular Pharmacology And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHMR 1098en_US
dc.subjectDiazoxideen_US
dc.subjectPinacidilen_US
dc.subjectK-ATP Channelen_US
dc.subjectIschemia Reperfusion Arrhythmiaen_US
dc.titleBoth mitochondrial K-ATP channel opening and sarcolemmal K-ATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male ratsen_US
dc.typeArticleen_US

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