Both mitochondrial K-ATP channel opening and sarcolemmal K-ATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats
Yükleniyor...
Dosyalar
Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sage Publications Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim This study was performed to assess The effect of selective sarcolemmal adenosine tnphosphate (ATP)-sensitive K+ channel (K-ATP) inhibition and the mitochondnal K-ATP channel activation on ischemia and reperfusion (I/R)-induced arrhythmias in different gender of rats We compared the effect of a selective sarcolemmal K-TAP channel blocker HMR 1098, a selective mitochondrial K-ATP channel opener diazoxide, a nonselective K-ATP channel opener pinacidil, and the combination of pinacidil with HMR 1098 on the incidence and duration of ventricular arrhythmias in 2 groups anesthetized males (n = 31) and females (n = 31) Main Methods ischema and reperfusion was produced by occluding the left main coronary artery of Sprague-Dowley rats for 6 minutes followed by re-opening of the artery for 6 minutes Key Findings The arrhythmia score and the duration of arrhythmias were significantly reduced by HMR 1098, diazoxide, and pinacidil in male rats The combination of the pinacidil with HMR 1098 did not change the antiarrhythmic effect of pinacidil The duration of arrhythmas was shorter in females than that in the corresponding males Drug treatments were not effective in decreasing arrhythmias in female groups to the same extent as in the male group However, the mitochondrial K-ATP channel activation that is provided by the combination of pinacidil with HMR 1098 significantly decreased the total length of arrhythmias in females Significance Results of the current study indicate that both mitochondnal K-ATP channel activation and sarcolemmal K-ATP channel inhibition exert antiarrhythmic action in male rats The antiarrthythmic effect of pinacidil is not depend on the sarcolemmal K-ATP channel opening These results also indicate that K-ATP channel modulators show no discernable effect in female rats due to the already low incidence of arrhythmias in females
Açıklama
Anahtar Kelimeler
HMR 1098, Diazoxide, Pinacidil, K-ATP Channel, Ischemia Reperfusion Arrhythmia
Kaynak
Journal Of Cardiovascular Pharmacology And Therapeutics
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
15
Sayı
4
