The antiinflammatory and electrophysiological effects of fingolimod on penicillin-induced rats

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dc.authorid0000-0001-8791-235Xen_US
dc.authorid0000-0002-3394-2438en_US
dc.authorid0000-0001-7035-3336en_US
dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0001-9865-1685en_US
dc.contributor.authorTürel, Canan Akünal
dc.contributor.authorÇelik, Hümeyra
dc.contributor.authorTorun, İbrahim Ethem
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorTürel, İdris
dc.date.accessioned2023-11-16T12:53:30Z
dc.date.available2023-11-16T12:53:30Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground The fact that inflammation triggers epileptic seizures brings to mind the antiepileptic properties of anti-inflammatory drugs.Objective To investigate the electrophysiological and anti-inflammatory effects of fingolimod on an experimental penicillin-induced acute epileptic seizure model in rats.Methods Thirty-two male Wistar rats were divided into four groups: control (penicillin), positive control (penicillin + diazepam [5 mg/kg]), drug (penicillin + fingolimod [0.3 mg/kg]) and synergy group (penicillin + diazepam + fingolimod). The animals were anesthetized with urethane, and epileptiform activity was induced by intracortical injection of penicillin (500,000 IU). After electrophysiological recording for 125 minutes, IL-1 beta, TNF-alpha, and IL-6 were evaluated by ELISA in the serum of sacrificed animals.Results During the experiment, animal deaths occurred in the synergy group due to the synergistic negative chronotropic effect of diazepam and fingolimod. Although not statistically significant, fingolimod caused a slight decrease in spike-wave activity and spike amplitudes in the acute seizure model induced by penicillin ( p > 0.05). Fingolimod decreased serum IL-1 beta ( p < 0.05); fingolimod and diazepam together reduced IL-6 ( p < 0.05), but no change was observed in serum TNF-alpha values.Conclusion Even in acute use, the spike-wave and amplitude values of fingolimod decrease with diazepam, anticonvulsant and anti-inflammatory effects of fingolimod will be more prominent in chronic applications and central tissue evaluations. In addition, concomitant use of fingolimod and diazepam is considered to be contraindicated due to the synergistic negative inotropic effect.en_US
dc.identifier.citationTürel, C. A., Çelik, H., Torun, İ. E., Çetinkaya, A., & Türel, İ. (2022). The antiinflammatory and electrophysiological effects of fingolimod on penicillin-induced rats. Arquivos de Neuro-Psiquiatria, 80(12), 1220-1226.en_US
dc.identifier.doi10.1055/s-0042-1758754
dc.identifier.endpage1226en_US
dc.identifier.issn0004-282X
dc.identifier.issn1678-4227
dc.identifier.issue12en_US
dc.identifier.pmid36580959en_US
dc.identifier.scopus2-s2.0-85145153482en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1220en_US
dc.identifier.urihttp://dx.doi.org/10.1055/s-0042-1758754
dc.identifier.urihttp://dx.doi.org/10.1055/s-0042-1758754
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11847
dc.identifier.volume80en_US
dc.identifier.wosWOS:000905807600006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTürel, Canan Akünal
dc.institutionauthorTorun, İbrahim Ethem
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorTürel, İdris
dc.language.isoenen_US
dc.publisherAssociação Arquivos de Neuro-Psiquiatriaen_US
dc.relation.ispartofArquivos de Neuro-Psiquiatriaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRatsen_US
dc.subjectFingolimod Hydrochlorideen_US
dc.subjectAnti-Inflammatory Agentsen_US
dc.subjectElectrophysiologyen_US
dc.subjectİnduced Epileptiform Activityen_US
dc.subjectNeuroinflammationen_US
dc.titleThe antiinflammatory and electrophysiological effects of fingolimod on penicillin-induced ratsen_US
dc.typeArticleen_US

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