Benefit of metformin in COPD: an effect on autonomic nervous system?

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dc.contributor.authorYaşar, Zehra
dc.contributor.authorErdem, Fatma
dc.contributor.authorTalay, Fahrettin
dc.date.accessioned2021-06-23T19:42:31Z
dc.date.available2021-06-23T19:42:31Z
dc.date.issued2015
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractTo the Editors: With great interest we read the recent article by Hitchings et al. on the safety of metformin in patients with type-2 diabetes mellitus and COPD (1). They found that in patients at high risk for lactate accumulation, metformin therapy was associated with a minor elevation of lactate concentration of doubtful clinical signifi cance. An additional fi nding was that metformin was associated with a longer survival, which was diffi cult to interpret because of possible unmeasured confounders. We would like to propose a mechanism of metformin by which metformin may have a benefi cial eff ect in terms of survival of COPD patients. Studies have shown that alterations in autonomic nervous system are present in COPD, with or without arterial COPD (2–6), which may contribution to the severity of disease and survival. Metformin is an anti-diabetic agent that has been shown to reduce insulin resistance and hyperglycemia, and also reduce the incidence of diabetes (7). Studies have also shown that metformin has benefi cial eff ects on autonomic control (8,9) and can improve cardiac sympathovagal balance in obese patients with type-2 diabetes (8). We think it can be hypothesized that the preceding eff ects of metformin on the autonomic nervous system might have played a role in the survival data reported by Hitchings et al.(1).en_US
dc.identifier.doi10.3109/15412555.2014.949003
dc.identifier.endpage345en_US
dc.identifier.issn1541-2555
dc.identifier.issn1541-2563
dc.identifier.issue3en_US
dc.identifier.pmid25222022en_US
dc.identifier.scopus2-s2.0-84933515368en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage344en_US
dc.identifier.urihttps://doi.org/10.3109/15412555.2014.949003
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8520
dc.identifier.volume12en_US
dc.identifier.wosWOS:000357245600014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYaşar, Zehra
dc.institutionauthorErdem, Fatma
dc.institutionauthorTalay, Fahrettin
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofCopd-Journal Of Chronic Obstructive Pulmonary Diseaseen_US
dc.relation.publicationcategoryEditöre Mektup - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutonomic Nervous Systemen_US
dc.subjectCOPDen_US
dc.subjectMetforminen_US
dc.titleBenefit of metformin in COPD: an effect on autonomic nervous system?en_US
dc.typeLetteren_US

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