Benefit of metformin in COPD: an effect on autonomic nervous system?
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Dosyalar
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Informa Healthcare
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
To the Editors:
With great interest we read the recent article by Hitchings et al. on the safety of metformin in patients with type-2 diabetes mellitus and COPD (1). They found that in patients at high risk for lactate accumulation, metformin therapy was associated with a minor elevation of lactate concentration of doubtful clinical signifi cance. An additional fi nding was that metformin was associated with a longer survival, which was diffi cult to interpret because of possible unmeasured confounders. We would like to propose a mechanism of metformin by which metformin may have a benefi cial eff ect in terms of survival of COPD patients. Studies have shown that alterations in autonomic nervous system are present in COPD, with or without arterial COPD (2–6), which may contribution to the severity of disease and survival. Metformin is an anti-diabetic agent that has been shown to reduce insulin resistance and hyperglycemia, and also reduce the incidence of diabetes (7). Studies have also shown that metformin has benefi cial eff ects on autonomic control (8,9) and can improve cardiac sympathovagal balance in obese patients with type-2 diabetes (8). We think it can be hypothesized that the preceding eff ects of metformin
on the autonomic nervous system might have played a role in the survival data reported by Hitchings et al.(1).
Açıklama
Anahtar Kelimeler
Autonomic Nervous System, COPD, Metformin
Kaynak
Copd-Journal Of Chronic Obstructive Pulmonary Disease
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
12
Sayı
3
