Dynamic thiol/disulphide homeostasis metrics as a risk factor for peripheral arterial disease

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dc.authorid0000-0002-6107-2943en_US
dc.authorid0000-0002-8212-7149
dc.authorid0000-0003-4709-4705
dc.authorid0000-0003-3655-1595
dc.authorid0000-0002-1012-837X
dc.contributor.authorKorkmaz, Ufuk Turan Kürşat
dc.contributor.authorYüksel, Ahmet
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorVelioğlu, Yusuf
dc.contributor.authorUçaroğlu, Erhan Renan
dc.contributor.authorErdem, Kemalettin
dc.date.accessioned2021-06-23T19:17:09Z
dc.date.available2021-06-23T19:17:09Z
dc.date.issued2021
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractObjective To examine dynamic thiol/disulphide homeostasis metrics as a novel risk factor of oxidative stress in patients with peripheral arterial disease. Methods One hundred patients with lower extremity peripheral arterial disease (a study group) and 100 control subjects were included in this prospective case-control study. Participants' baseline clinical characteristics and laboratory data including some oxidant/antioxidant status parameters such as albumin, ferroxidase and myeloperoxidase, and thiol/disulphide homeostasis parameters such as native thiol, total thiol and disulphide, as well as native thiol/total thiol, disulphide/native thiol and disulphide/total thiol ratios were all recorded and then compared between the groups. Results Mean albumin and ferroxidase, and median myeloperoxidase levels were found to be significantly higher in patients with the peripheral arterial disease than in control group (p = 0.045,p = 0.000 andp = 0.000, respectively). Mean native thiol and total thiol, and median disulphide levels were found to be significantly lower in the study group as compared with the control group (p = 0.000,p = 0.000 andp = 0.037, respectively). According to the results of logistic regression analysis, systolic blood pressure, ferroxidase and myeloperoxidase levels were detected to be the independent predictors of peripheral arterial disease. Conclusion Our report is the first one in the literature investigating dynamic thiol/disulphide homeostasis metrics as a novel risk factor of oxidative stress in peripheral arterial disease. Dynamic thiol/disulphide homeostasis metrics may be used as a valuable risk factor of oxidative stress in patients with the peripheral arterial disease since it is readily available, easily calculated and relatively cheap.en_US
dc.identifier.doi10.1177/1708538120947245
dc.identifier.endpage255
dc.identifier.issn1708-5381
dc.identifier.pmid32772842en_US
dc.identifier.scopus2-s2.0-85089249269en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage248
dc.identifier.urihttps://doi.org/10.1177/1708538120947245
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5260
dc.identifier.volume29
dc.identifier.wosWOS:000559615800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKorkmaz, Ufuk Turan Kürşat
dc.institutionauthorYüksel, Ahmet
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorVelioğlu, Yusuf
dc.institutionauthorUçaroğlu, Erhan Renan
dc.institutionauthorErdem, Kemalettin
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofVascularen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThiolen_US
dc.subjectDisulphide Homeostasisen_US
dc.subjectOxidative Stressen_US
dc.subjectNovelen_US
dc.subjectRisk Factoren_US
dc.subjectBiomarkeren_US
dc.subjectPeripheral Arterial Diseaseen_US
dc.titleDynamic thiol/disulphide homeostasis metrics as a risk factor for peripheral arterial diseaseen_US
dc.typeArticleen_US

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