The effect of ethanol intake on tendon healing: a histological and biomechanical study in a rat model

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dc.authorid0000-0002-4060-3354en_US
dc.authorid0000-0001-8154-658X
dc.authorid0000-0003-2153-7774
dc.authorid0000-0003-2696-8274
dc.contributor.authorHapa, Onur
dc.contributor.authorÇakıcı, Hüsamettin
dc.contributor.authorGideroğlu, Kaan
dc.contributor.authorÖzturan, Kutay
dc.contributor.authorKükner, Aysel
dc.contributor.authorBuğdaycı, Güler
dc.date.accessioned2021-06-23T19:26:02Z
dc.date.available2021-06-23T19:26:02Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractEthanol has a suppressive effect on inflammation and the immune system, but the effect of ethanol on tendon healing in vivo has not been studied. The purpose of this study was to investigate the histological and biomechanical effects of ethanol intake on tendon healing in a rat tendon injury model. Forty-seven rats were randomly assigned to either ethanol or control groups. Progressively increasing concentrations of ethanol combined with glucose were administered to these rats in their drinking water. After 1 week, the Achilles tendon of each rat was injured proximal to its insertion on the calcaneus. All rats were euthanized at 4 weeks. The tendons were evaluated both histologically and biomechanically. The histologic examination of these tendons was done using a semi-quantitative 4-point scale to rate cell morphology, the degree of ground substance staining, collagen organization, and vascular changes. Load to failure (N) strength was obtained with biomechanical testing. Tendon failure loads were lower in the ethanol group (31.6 +/- A 8.8 N) than in the control group (39.7 +/- A 8.2 N) (P = 0.04). Histologic tenocyte scores were higher in the ethanol group (1.90 +/- A 0.73) than the control group (0.9 +/- A 0.73) (P = 0.01). Ethanol ingestion resulted in abnormal tenocyte morphology, disorganized collagen bundles with a tendency toward increased tenocyte number, and neovascularization 3 weeks after the tendon injury indicating delayed and abnormal healing. The healing tendons in the alcohol treated group failed at statistically lower loads than the control group.en_US
dc.identifier.doi10.1007/s00402-009-0877-x
dc.identifier.endpage1726en_US
dc.identifier.issn0936-8051
dc.identifier.issn1434-3916
dc.identifier.issue12en_US
dc.identifier.pmid19381661en_US
dc.identifier.scopus2-s2.0-70450248720en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1721en_US
dc.identifier.urihttps://doi.org/10.1007/s00402-009-0877-x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6384
dc.identifier.volume129en_US
dc.identifier.wosWOS:000271538400022en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇakıcı, Hüsamettin
dc.institutionauthorGideroğlu, Kaan
dc.institutionauthorÖzturan, Kutay
dc.institutionauthorKükner, Aysel
dc.institutionauthorBuğdaycı, Güler
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofArchives Of Orthopaedic And Trauma Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEthanolen_US
dc.subjectTendonen_US
dc.subjectHealingen_US
dc.subjectLoad To Failure Strengthen_US
dc.subjectBiomechanical Testingen_US
dc.titleThe effect of ethanol intake on tendon healing: a histological and biomechanical study in a rat modelen_US
dc.typeArticleen_US

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