Thymoquinone Inhibits neurogenic Inflammation underlying migraine through modulation of calcitonin gene-related peptide release and stabilization of meningeal mast cells in glyceryltrinitrate-ınduced migraine model in rats

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dc.authorid0000-0001-9261-2634en_US
dc.authorid0000-0001-5912-9392
dc.authorid0000-0002-1668-7850
dc.authorid0000-0002-4060-3354
dc.contributor.authorKılınç, Erkan
dc.contributor.authorTöre, Fatma
dc.contributor.authorDağıstan, Yaşar
dc.contributor.authorBuğdaycı, Güler
dc.date.accessioned2021-06-23T19:55:00Z
dc.date.available2021-06-23T19:55:00Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractTwo main contributors of sterile neurogenic inflammation underlying migraine pain, calcitonin gene-related peptide (CGRP), and meningeal mast cells (MMCs) play a key role in the activation of the inflammatory cascade resulting in the sensitization of trigeminal nociceptors. It is well established that phytochemical agent thymoquinone exhibits multiple anti-inflammatory effects in different in vitro and in vivo models of neuroinflammation. But its effects on the CGRP release and meningeal mast cells are unknown. In the present study, we investigated the effects of thymoquinone on the CGRP release in migraine-related strategic structures which are crucial targets for anti-migraine drugs, and on the MMCs in glyceryl trinitrate (GTN)-induced in vivo migraine model as well as in the ex vivo meningeal preparations in rats. Anti-inflammatory thymoquinone ameliorated GTN-stimulated CGRP levels in plasma, and migraine-related structures including trigeminal ganglion and brainstem; moreover, thymoquinone inhibited degranulation of MMCs and prevented the increase in the number of MMCs in GTN-induced in vivo migraine model. However, in the ex vivo meningeal preparations, thymoquinone did not inhibit the GTN-induced CGRP release from trigeminal meningeal afferents. Our findings suggest that thymoquinone mediates modulation of CGRP release in trigeminal ganglion neurons and brainstem, and stabilization of MMCs. Thus, thymoquinone may be a promising candidate to prevent the meningeal neurogenic inflammation and consequently migraine.en_US
dc.identifier.doi10.1007/s10753-019-01115-w
dc.identifier.endpage273en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue1en_US
dc.identifier.pmid31707574en_US
dc.identifier.scopus2-s2.0-85074836211en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage264en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-019-01115-w
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10703
dc.identifier.volume43en_US
dc.identifier.wosWOS:000495308000001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKılınç, Erkan
dc.institutionauthorDağıstan, Yaşar
dc.institutionauthorBuğdaycı, Güler
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeurogenic Inflammationen_US
dc.subjectMigraineen_US
dc.subjectThymoquinoneen_US
dc.subjectMeningeal Mast Cellsen_US
dc.subjectCGRPen_US
dc.titleThymoquinone Inhibits neurogenic Inflammation underlying migraine through modulation of calcitonin gene-related peptide release and stabilization of meningeal mast cells in glyceryltrinitrate-ınduced migraine model in ratsen_US
dc.typeArticleen_US

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