Efficacy of aprotinin treatment on bilateral blunt chest trauma created in rab

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dc.authorid0000-0001-8265-9615
dc.authorscopusid7102340089
dc.authorscopusid55548528800
dc.authorscopusid57197314713
dc.authorscopusid9844116800
dc.authorscopusid7101877759
dc.authorscopusid55358223900
dc.authorscopusid59114481800
dc.contributor.authorKaya, Halil
dc.contributor.authorKafalı, Mehmet Ertuğrul
dc.contributor.authorAydın, Kemal
dc.contributor.authorKoçak, Sedat
dc.contributor.authorŞahin, Mustafa
dc.contributor.authorGül, Mehmet
dc.contributor.authorCander, Başar
dc.date.accessioned2024-09-25T19:42:55Z
dc.date.available2024-09-25T19:42:55Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: To investigate the effects of aprotinin, on blood gasses, oxidant-antioxidant status, and lung histopathology in an experimental bilateral blunt chest trauma model. Methods: Conducted at the Experimental Animal Laboratory of Meram Medical School at Selcuk University, Konya, Turkey, the study comprised 21 New Zealand female albino rabbits who were divided into three groups. Trauma was applied on the sham and aprotinin groups, which was administered intravenous Aprotinin 20.000 U/kg. Arterial blood samples were obtained from all rabbits at hours 0, 3, 24, and 96. At hour 96 after trauma, all rabbits were sacrificed using the decapitation method, and then blood and lung tissue samples were obtained. Blood nitric oxide, malondialdehyde and blood gas measurements were made. Histopathological changes in the lung were examined with a light microscope. Results: While no positive effect of aprotinin was observed on nitric oxide malondialdehyde and partial pressure of carbon dioxide values, it was seen to have an increasing effect on partial oxygen pressure level. Aprotinin had a partial effect on lung histopathology. Conclusion: Aprotinin was determined to have a positive effect on PO2 levels. We could not find any positive effects especially on alveolar haemorrhage.en_US
dc.identifier.endpage37en_US
dc.identifier.issn0030-9982
dc.identifier.issue1en_US
dc.identifier.pmid23865129en_US
dc.identifier.scopus2-s2.0-84872017505en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage32en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12355
dc.identifier.volume63en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKoçak, Sedat
dc.institutionauthorGül, Mehmet
dc.institutionauthorCander, Başar
dc.institutionauthorid0000-0001-8265-9615
dc.language.isoenen_US
dc.relation.ispartofJournal of the Pakistan Medical Associationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzYK_20240925en_US
dc.subjectAcute Lung Injuryen_US
dc.subjectAprotininen_US
dc.subjectPulmonary Contusionen_US
dc.subjectTraumaen_US
dc.titleEfficacy of aprotinin treatment on bilateral blunt chest trauma created in raben_US
dc.typeArticleen_US

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