Exogenous melatonin treatment reduces hepatocyte damage in rats with experimental acute pancreatitis

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dc.authorid0000-0002-4060-3354en_US
dc.authoridDinler, Kahraman
dc.authoridHasdemir, Oğuz
dc.authoridBüyükaşık, Oktay
dc.authoridBuğdaycı, Güler
dc.authoridTerzi, Hakan
dc.authorid0000-0001-8540-1935
dc.contributor.authorÇöl, Cavit
dc.contributor.authorDinler, Kahraman
dc.contributor.authorHasdemir, Oğuz
dc.contributor.authorBüyükaşık, Oktay
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorTerzi, Hakan
dc.date.accessioned2021-06-23T19:26:51Z
dc.date.available2021-06-23T19:26:51Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground/purpose The hormone melatonin affects cellular immunity in particular and the immune system in general both directly and indirectly. We report our evaluation of the effects of decreasing and increasing serum melatonin levels on hepatocyte damage in rats with experimental acute pancreatitis. Methods Winstar Albino rats with experimentally induced acute pancreatitis were divided into three groups of ten rats each: (1) control (induced acute pancreatitis only); (2) rats with induced acute pancreatitis plus surgical pinealectomy (no melatonin injections); (3) rats with induced acute pancreatitis plus injections of exogenous melatonin. The effects of melatonin levels were evaluated using biochemical and histopathological parameters. Results Rats undergoing the pinealectomy had increased amylase and lactate dehydrogenase (LDH) levels, while those receiving injections of exogenous melatonin had decreased amylase, aspartate transaminase, LDH, and bilirubin levels but increased levels of alanine transferase levels. Conclusion Melatonin may have a therapeutic or protective effect on acute pancreatitis and obstructive jaundice.en_US
dc.identifier.doi10.1007/s00534-010-0265-5
dc.identifier.endpage687en_US
dc.identifier.issn1868-6974
dc.identifier.issn1868-6982
dc.identifier.issue5en_US
dc.identifier.pmid20464559en_US
dc.identifier.scopus2-s2.0-79952111313en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage682en_US
dc.identifier.urihttps://doi.org/10.1007/s00534-010-0265-5
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6671
dc.identifier.volume17en_US
dc.identifier.wosWOS:000280845100022en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇöl, Cavit
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Hepato-Biliary-Pancreatic Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Pancreatitisen_US
dc.subjectHepatocyte Damageen_US
dc.subjectMelatoninen_US
dc.titleExogenous melatonin treatment reduces hepatocyte damage in rats with experimental acute pancreatitisen_US
dc.typeArticleen_US

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