HLA in alopecia areata

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dc.authorid0000-0002-4679-1181en_US
dc.authorid0000-0002-2279-0184
dc.authorid0000-0003-3864-4752
dc.contributor.authorKavak, Ayşe
dc.contributor.authorBaykal, Can
dc.contributor.authorÖzarmağan, Güzin
dc.contributor.authorAkar, Uğur
dc.date.accessioned2021-06-23T19:17:18Z
dc.date.available2021-06-23T19:17:18Z
dc.date.issued2000
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground The aim of this study was to investigate the human leukocyte antigen (HLA) characteristics of Turkish alopecia areata patients, and the correlation of the HLA profile with age of onset, severity and duration of the disease, presence of ophiasis, and family history. Methods A total of 88 patients with alopecia areata, alopecia totalis, or alopecia universalis were compared with 100 healthy controls. HLA typing was performed by the Terasaki microlymphocytotoxicity method. Results The frequency of HLA-A1, HLA-B62(15), HLA-DQ1, and HL4-DQ3 was significantly higher in patients than in controls. HL4-DR16 was significantly less common in patients than in the control group, and we concluded that this allele might have a protective role for alopecia areata. Juvenile onset and severe involvement were related with HLA-Cw7 and HLA-DR1, respectively. The HLA profile was independent of the existence of long-standing disease, presence of ophiasis, and a positive family history. Conclusions In HLA-alopecia areata association, ethnic differences may play a role.en_US
dc.identifier.doi10.1046/j.1365-4362.2000.00921.x
dc.identifier.endpage592en_US
dc.identifier.issn0011-9059
dc.identifier.issue8en_US
dc.identifier.pmid10971726en_US
dc.identifier.scopus2-s2.0-0033816656en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage589en_US
dc.identifier.urihttps://doi.org/10.1046/j.1365-4362.2000.00921.x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5349
dc.identifier.volume39en_US
dc.identifier.wosWOS:000089156900005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKavak, Ayşe
dc.language.isoenen_US
dc.publisherBlackwell Science Ltden_US
dc.relation.ispartofInternational Journal Of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHLAen_US
dc.subjectAlopecia Areata
dc.subjectTerasaki Microlymphocytotoxicity
dc.titleHLA in alopecia areataen_US
dc.typeArticleen_US

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