HLA in alopecia areata

Yükleniyor...
Küçük Resim

Tarih

2000

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Blackwell Science Ltd

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Background The aim of this study was to investigate the human leukocyte antigen (HLA) characteristics of Turkish alopecia areata patients, and the correlation of the HLA profile with age of onset, severity and duration of the disease, presence of ophiasis, and family history. Methods A total of 88 patients with alopecia areata, alopecia totalis, or alopecia universalis were compared with 100 healthy controls. HLA typing was performed by the Terasaki microlymphocytotoxicity method. Results The frequency of HLA-A1, HLA-B62(15), HLA-DQ1, and HL4-DQ3 was significantly higher in patients than in controls. HL4-DR16 was significantly less common in patients than in the control group, and we concluded that this allele might have a protective role for alopecia areata. Juvenile onset and severe involvement were related with HLA-Cw7 and HLA-DR1, respectively. The HLA profile was independent of the existence of long-standing disease, presence of ophiasis, and a positive family history. Conclusions In HLA-alopecia areata association, ethnic differences may play a role.

Açıklama

Anahtar Kelimeler

HLA, Alopecia Areata, Terasaki Microlymphocytotoxicity

Kaynak

International Journal Of Dermatology

WoS Q Değeri

Q3

Scopus Q Değeri

Q2

Cilt

39

Sayı

8

Künye